Phosphorylation by Akt kinases leads to activation/deactivation of target genes, promoting the downstream effects of the PI3K-Akt pathway. Some of the cytoplasmic targets of Akt are listed with aliases in parentheses, full names and links to gene report pages:
Chuk (Ikka, IKK1) – conserved helix-loop-helix ubiquitous kinase
Ikbkb (IKKB, IKK2) – inhibitor of nuclear factor kappa B kinase subunit beta
Bad – Bcl2-associated agonist of cell death
Tsc2 (tuberous sclerosis 2) – TSC complex subunit 2
Mdm2 (Mdm2 p53 binding protein homolog (mouse)) – MDM2 proto-oncogene
Casp9 – caspase 9
Nos3 (eNos) – nitric oxide synthase 3
Targets of Akt2 in the insulin responsive glucose transport pathway mediated by Glut4 are listed with aliases in parentheses, full names and links to gene report pages; the effect of phosphorylation by Akt2 is also mentioned:
TBC1D4 (AS160) – TBC1 domain family member 4 (Note that the human gene is shown as there is no rat ortholog in the database; the putative rat ortholog is not cited by Entrez in HomoloGene, as the rat LOC686547, RGD:1596351 was not annotated on the reference assembly.) Akt2 phosphorylation effect: inhibitory.
Stxbp4 (Synip) – syntaxin binding protein 4 Akt2 phosphorylation effect: inhibitory.
Myo5a (myosin 5a, Myosin Va) – myosin VA Akt2 phosphorylation effect: activating.