Adenylate cyclase members

There are nine membrane-bound adenylyl cyclases (AC) and one soluble AC. All ACs are stimulated by the activated Gs alpha subunit of heterotrimeric G proteins. Some can also be activated by CaM or the beta/gamma subunits of heterotrimeric G proteins. Protein kinases inhibit (PKA) or either inhibit or activate (PKC) particular ACs. PKA inhibits the AC5 and AC6 members, thus providing a small negative feedback. The adenylyl cyclase members are listed with aliases in parentheses, full names and links to gene report pages:

Adcy1 (AC1) – adenylate cyclase 1
Adcy2 (adenylate cyclase 2 (brain)) – adenylate cyclase 2
Adcy3 (type III adenylyl cyclase) – adenylate cyclase 3
Adcy4 (adenylate cyclase type IV) – adenylate cyclase 4
Adcy5 (adenylyl cyclase type V) – adenylate cyclase 5
Adcy6 (ADCYB, ACVI) – adenylate cyclase 6
Adcy7 (adenylyl cyclase 7)– adenylate cyclase 7
Adcy8 (type VIII adenylyl cyclase, Ac8) – adenylate cyclase 8
Adcy9 (adenylate cyclase type 9) – adenylate cyclase 9
Adcy10 (Sac, soluble adenylyl cylase) – adenylate cyclase 10