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 Rat Strain Models 

 

Rat Strain Models for Immune and Inflammatory Diseases

Experimental Allergic Encephalomyelitis Models

AS/Ztm

These were immunized with guinea-pig spinal cord to produce 100 per cent incidence of EAE (REF RGD ID: 704436)

Crl:WI(Han)

These are resistant to EAE (REF RGD ID: 704436

Experimentally Induced Arthritis Models

ACI/SegHsd 

These are resistant to type II collagen induced arthritis (REF RGD ID 1285224)

BN/SsNHsd 

These are resistant to experimentally induced arthritis by collagen.(REF RGD ID 61067)

BBDR/Wor 

These are susceptible to experimentally induced arthritis by collagen and experimentally induced autoimmune thyroid diseases, but resistant to spontaneous insulin-dependent diabetes and spontaneous autoimmune thyroid diseases.(REF RGD ID 61067)

E3/ZtmRhd 

These are resistant to Pristane-induced arthritis (REF RGD ID 631850).

DA/Bkl 

Progressive, symmetric inflammation which characterizes arthritis can be induced in rats by multiple triggering stimuli that regulate disease expression (for example MHC and non-MHC genetic loci).  DA rats are susceptible to arthritis which is induced with homologous or heterologous type II collagen in incomplete Freund’s adjuvant (IFA) (REF RGD ID 631168), Mbt-AIA, avridine-induced arthritis (REF RGD ID 631168)., Pristane-induced arthritis (REF RGD ID 631850) and Oil-induced arthritis (REF RGD ID 631168).

F344/NHsd

These rats are resistant to type II collagen in incomplete Freund’s adjuvant (IFA) (REF RGD ID 631168), Mbt-AIA, avridine-induced arthritis (REF RGD ID 631168)., Pristane-induced arthritis (REF RGD ID 631850) and Oil-induced arthritis (REF RGD ID 631168).

Multiple Sclerosis Models

DA/Han

Susceptible to Multiple Sclerosis. Perivenous inflammation restricted to CNS associated with primary demyelination resulting in large confluent demyelinated plaques; higher serum levels of anti-MOG IgG, IgG2a, IgG2b, IgG2c than ACI/SegHsd (REF RGD ID: 69712). Develops paralysis with two to three relapses (REF RGD ID: 61031). Hemiparalysis, relapsing/remitting disease in ~70% in MOG induced disease (REF RGD ID: 1302437)

LEW.1AV1

Susceptible to Multiple Sclerosis. High demyelination and inflammation indices with MOG induction, acute lethal 25%; monophasic 19%; relapsing/remitting 33%; primary progressive 6.3%, impaired balance 8.3% (REF RGD ID: 629629)

ACI/SegHsd

Resistant to Multiple Sclerosis. 1/21 showed demyelination with 50µg rMOG(aa 1-125) and spinal cord lesions (REF RGD ID: 69712).

E3/Han

Resistant to Multiple Sclerosis. 0/15 incident rate with spinal cord homogenate (REF RGD ID: 61031).

LER/N

Resistant to active induction of EAE but susceptible to transferred EAE when injected with encephalitogenic T cells (REF RGD ID: 724738)

PVG.1AV1

Resistant to Multiple Sclerosis. 4/61 incident rate with 20µg rMOG(aa 1-125)(REF RGD ID: 629629)

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