Introduction to RGD Genes
One definition of a gene is "the DNA sequence necessary and sufficient to express the complete complement of functional products derived from a unit of transcription". Gene report pages at RGD provide information about each gene that is annotated manually by curators and brought in via automated pipelines from other databases. Splice variants for each gene are listed in the gene report and specific information about these can be found in the associated splice variant report. The reports do not include variations such as mutations, pseudogenes or protein products which are derived from the modification of precursor proteins (eg. Agt produces the product angiotensinogen which is cleaved by Ren (renin) to produce angiotensin. Both Agt and Ren are gene objects whereas angiotensin, being a product of the cleavage and not have its own coding sequence, is not included). RGD works closely with Mouse Genome Informatics and the HUGO Gene Nomenclature Committee in assigning gene symbols and names for rat, human and mouse orthologs. Click on these two references for additional information: 6482191, 6482192.