Genes for Rat QTL

This page lists the genes for rat disease phenotypes that have been identified by positional cloning since 1999. The table below was compiled from the published literature. Every effort is made to keep this complete as new genes are identified, however, checking PubMed would also be worthwhile.

 

Genes for rat disease phenotypes identified by positional cloning from 1999
GenePhenotype
Suceptible StrainDateComplementationHuman TraitReference
Cd36Insulin resistance, hyperlipidaemia
SHR
1999,2001
Yes
Dyslipidaemia, insulin resistance, hypertension

Aitman, etal. Nat. Genet. 1999 21:76-83

Pravenec etal. Nat. Genet. 2001 27:156-8

MertkRetinal dystrophyRCS  2000, 2001
  

D'Cruz etal. Hum. Mol. Genet. 2000 9:645-51

Vollrath etal. PNAS 2001 98:12584-89 

AtrnHypomyelination, mahogany coat colorZI  2001  Kuramoto etal. PNAS 2001 98:559-64
Ncf1 Pristane induced arthritisDA 2002  Olofsson etal. Nat. Genet. 2003 33:25-32 
CblbType 1 diabetesKDP 2002  Yokoi etal. Nat. Genet. 2002 31:391-4
Gimap5 (Ian4)
Type 1 diabetesBB 2002  

Hornum etal. Diabetes 2002 51:1972-9

MacMurray etal. Genome Res. 2002 12:1029-39 

PKHD1Polycystic kidney diseasesd Pck-/- 2002  Polycystic kidney diseaseWard etal. Nat. Genet. 2002 30:259-69
Rab38Platelet storage pool disease, Renal FailureFH, LE, FHH
 2004,2005   
C2ta (Mhc2ta)MHC expressionDA 2005  Rheumatoid arthritis, multiple sclerosis, myocardial infarctionSwanberg etal. Nat. Genet. 2005 37:486-94
Fcgr3Crescentic glomerulonephritisWKY 2006  SLE, systemic autoimmunityRangel-Filho etal. J. Am. Soc. Nephrol. 2005 16:852-6
Fbxo10, Frmpd1Breast cancerWF 2007  Breast cancerOiso etal. Mamm. Genome 2004 15:307
Srebf1Hepatic steatosisSHR 2008  Pravenec et al. Hypertension 2008 51:148-53