Custom Rats

Knockouts

The PhysGen Knockout program ("Mechanistic Characterization of Genes for Hypertension and Renal Disease") aims to knock out a large number of genes nominated by genome wide association studies, combine these gene knockouts (KO) with hypertensive and normotensive strains, and phenotypically characterize them.


MCW Gene Editing Rat Resource Center

The National Heart, Lung, and Blood Institute (NHLBI) has awarded Howard Jacob, PhD and the Medical College of Wisconsin an R24 Resource grant to make ~200 genetically modified rat strains over the next five years. These models will be of interest and value to the mission of the NHLBI. The NHLBI promotes the prevention and treatment of heart, lung, and blood diseases through scientific discovery directed toward the causes of disease and translation of basic discoveries into clinical practice.

The rat strains will be made using several different gene editing technologies, making it feasible to genetically modify genes in rats in any desired background much faster than traditional technology.