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Cancer Portal - Related Links

Databases and Websites:

RGD Interactive Pathway Suite Network Diagrams

  Gene Expression and Regulation Pathway Suite Network Network includes:

    Transcription and Transcription-Coupled Events Pathway Suite Suite includes:
      RNA polymerase I transcription pathway
      RNA polymerase II transcription pathway
      RNA polymerase III transcription pathway
      Spliceosomal pathway

    Epigenetic Regulation/Control – Chromatin Modification/Remodeling
    Pathway Suite Suite includes:
      Chromatin remodeling pathway
      DNA modification pathway
      Histone modification pathway

  Glucose Homeostasis Pathway Suite Network Network includes:

    Pathway Suite for the Metabolism of Glucose and Related Molecules Pathways
    Suite includes:
      Glycolysis pathway
      Pyruvate metabolic pathway
      Pentose phosphate pathway
      Hexosamine biosynthetic pathway
      Glycogen biosynthetic pathway
      Gluconeogenesis pathway
      Glycogen degradation pathway

  S-adenosylmethionine Homeostasis Pathway Suite Network Network includes:

    SAM-homeostasis-related Metabolic Pathway Suite Suite includes:
      Methionine cycle/metabolic pathway
      Homocysteine metabolic pathway
      Folate cycle metabolic pathway
      Polyamine metabolic pathway

RGD Interactive Pathway Suite Diagrams

  Calcium Homeostasis Pathway Suite Suite includes:
    Calcium transport pathway
    Calcium/calcium-mediated signaling pathway
    Calcium signaling pathway via the calcium-sensing receptor
    Parathyroid hormone signaling pathway
    Calcium/calmodulin dependent kinase 2 signaling pathway

    Doxorubicin Pathway Suite Suite includes:
      Doxorubicin drug pathway
      Doxorubicin response pathway
      Doxorubicin pharmacodynamics pathway
      Doxorubicin pharmacokinetics pathway

    Prostate Cancer Pathway Suite Suite includes:
      Steroid hormone biosynthetic pathway
      Testosterone biosynthetic pathway
      Androgen signaling pathway
      Altered androgen signaling pathway
      Altered p53 signaling pathway
      Prostate cancer pathway

RNA Maturation, Transport and Surveillance (QC) and Protein Translation Pathway Suite Suite includes:
  Spliceosomal pathway
  mRNA nuclear export pathway
  Ribosome biogenesis pathway
  Translation pathway

Pathway Suite for the Glucose Homeostasis-related Regulatory and Signaling Pathways Suite includes:
  Insulin Secretion Pathway
  Insulin Responsive Facilitated Sugar Transporter Mediated Glucose Transport Pathway
  Insulin Signaling Pathway
  Glucagon Signaling Pathway

SAM-homeostasis-related Regulatory Pathway Suite Suite includes:
  DNA modification pathway
  Histone modification pathway

DNA Damage Response Pathway Suite Suite includes:
  Mismatch repair pathway
  Nucleotide excision repair pathway
  Non-homologous end joining pathway of double-strand break repair
  Homologous recombination pathway of double-strand break repair
  Ataxia telangiectasia-mutated (ATM) signaling pathway
  p53 signaling pathway
  Intrinsic apoptotic pathway

Estrogen Pathway Suite
Suite includes:
  Estradiol biosynthetic pathway
  Estrogen signaling pathway
  Anti-estrogen drug pathway
  Cholesterol biosyntheic pathway
  Sterol regulatory element-binding protein signaling pathway
  Bisphenol A response pathway

    RGD Interactive Pathway Diagrams
       axitinib drug pathway
       colorectal cancer pathway
       endometrial cancer pathway
       gefitinib drug pathway
       non-small cell lung cancer pathway
       pancreatic cancer pathway
       renal cell cancer pathway

  RGD Phenotypes and Models:  Mammary Cancer

  The Genetics of Breast Cancer

U.S. National Library of Medicine Genetics Home Reference
       Health Conditions A-Z
       Cancers A-Z

  National Cancer Institute
        NCI Data Catalog
        NCI Cancer Genomics
        NCI Cancer Biology
        NCI Bioinformatics and Cancer

  The Cancer Genome Atlas

  The Tumor Gene Family of Databases

  Centers for Disease Control and Prevention -  Cancer Prevention and Control

  The Danish Centre for Translational Breast Cancer Research

  OMIM Home Page
          OMIM - Breast Cancer
          OMIM - Prostate Cancer
          OMIM - Renal Cell Carcinoma
          OMIM - Bladder Cancer
          OMIM - Testicular Tumors
          OMIM - Cervical Cancer
          OMIM - Ovarian Cancer, Epithelial

  GeneCards Home Page

  The Human Gene Mutation Database

  NCBI - Genes and Disease Home Page
          Genes and Disease - Cancers
          Genes and Disease - Breast and Ovarian Cancer
          Genes and Disease - Prostate Cancer
          Genes and Disease - Polycystic Kidney Disease
          Genes and Disease - Small Cell Lung Carcinoma

  Genetic Association Database Home Page Please note that the Genetic Association Database has been retired. This link will take you to a page with options to download the data from August 2014.

  Mouse Tumor Biology

  The Immunology Link Cancer Information Page

(Please note that this list is intended to suggest locations for more information and is not intended to be exhaustive.  However, if you believe your website or database should be included in this list, please contact us to let us know about your resource.)

Links to Cancer-related Videos:

Pathways to Cancer
This 3D video explains how a signaling pathway begins with the arrival of a chemical signal all the way to the released proteins around the cell.

Tumor Growth
Cancer happens when cells divide uncontrollably and produce a growing lump or tumor. Watch this 3D animation to learn more.

Review Articles:

Models of genetic susceptibility to breast cancer.  Antoniou and Easton, Oncogene. 2006 Sep 25;25(43):5898-905

Mammary cancer susceptibility: human genes and rodent models.  Szpirer and Szpirer, Mamm Genome. 2007 Dec;18(12):817-31

The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis.  Shull JD  Breast Dis. 2007;28:69-86

Genetically engineered rat models for breast cancer.  Smits et al, Breast Dis. 2007;28:53-61

Sleeping beauty: a novel cancer gene discovery tool.  Dupuy et al, Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R75-9

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