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RGD > Help > Strains

Strains Help
Help Index
Definition
Finding info
Related info/link
Report
  • What is a Strain?
  • How do I find information about a Strain?
  • What information do you have on each Strain?
  • What other information can I get to via a Strain?
  • Let me start searching...

 

RGD Definition

"Rats that are used in a laboratory come from different sources; most of these are derived from Rattus norvegicus. An inbred strain is one whose background can be defined and is named by the nomenclature conventions."

Normally the strains are named following the nomenclature guidelines. This is generally a unique, brief symbol made up of upper case, roman letters or a combination of letters and numbers beginning with a letter.

Rat Strain Registration:

RGD is endeavouring to create a comprehensive list of Rat strains in use by the community so that information about strain characteristics and availability can be maintained and made available to the widest audience. We are looking for community support in this effort in the following ways:

  • If you maintain rat strains at your institution, please send us the information using our online registration form at RGD
  • If you are in the process of developing a new strain please inform strains@rgd.mcw.edu. We can assist in naming your strain and can reserve that symbol for you.

Strain Submission:

Please contact strains@rgd.mcw.edu to submit your strain data. We can send the strain template and the guidelines for completing the template.

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Finding Strain information

1. Using the General Search

The general RGD search available at the top of each page is a quick route to finding strains. This will search Strain symbols and names only. (See General RGD Search help for more information).

2. Using the Strain Search Form - Provides more customizable options

Quick Guide

  1. The users have a choice to search the strains by entering any of the keywords that describe a strain or they can even highlight the search fields already available to them and then click search strains to get all the information regarding a strain of interest
  2. Users also have a choice to view the list of strains available in RGD and highlight the strain of their interest to get a detailed report for this strain. TIP: to facilitate scrolling down highlight the column and enter the first letter of the strain of interest

Note: Selecting a 'primary' strain such as BN (no substrain designation) will show the data for BN and all associated substrains of BN in RGD (BN/Cub-lx, BN/SsNHsd, etc). Selecting a strain with a specific substrain designation will show you the data for that strain alone. This is to facilitate comparison of strains and substrain information.

Below is a more detailed explanation of each element of the search form, which will allow you greater flexibility to refine your searches.

RGD: Strain Query Form Help

Strain Symbol/Alias/Keyword

Enter a strain symbol, alias or keyword to search for. The asterisk '*' is an accepted wildcard. Sample keyword searches include Hypertension, Diabetes, cancer, etc. The returned list of hits shows the keyword in the context of the text in the strain record to aid in identification of meaningful hits.

Search Fields

Restrict the strain fields searched, multiple selections are allowed, the fields contain information on the following:

  • Symbol - the strain symbol itself
  • Origin - text describing the origin of the strain or colony.
  • Anatomy - anatomical notes about the strain
  • Behavior - observations on the behavior of the strain
  • Drugs and Chemicals - interactions and responsiveness to various drugs and chemicals
  • Immunology - Immunological notes about the strain
  • Infection - Susceptibility and response to infection
  • Lifespan and Spontaneous Disease - Typical lifespan of this strain, known disease-susceptibilities
  • Physiology and Biochemistry - results pertaining to the physiology or biochemistry of this strain
  • Reproduction - notes on the reproductive success of this strain, litter sizes, etc.

 

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Related Information/Links

The strain report contains links to information and resources related to this strain, including QTLs mapped using this strain and references containing information about these strains.

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The Strain Report

The following fields are present on the Strain report:

RGD: Strain Report Help

Symbol

The official strain symbol (combination of strain and substrain designations)

Strain

The official strain symbol

Substrain

The official substrain symbol - typically this is a collection of ILAR lab codes defining the history of this particular strain.

Full Name

The common full text name for the strain

Source

Known labs or companies who can provide this strain to other researchers.

Type

Type of strain - inbred, congenic, consomic, outbred.

See Also

Links to other substrains of this strain, or the main strain for this substrain. These pages often have extra information about a particular strain, especially the parental strain page (e.g. BN would be the parental strain for the BN/Ssn substrain).

Genetic Markers

Genotype for standard genetic markers used in the characterization of inbred strains.

Coat Color

The coat color of this strain - e.g. Albino, brown, white.

Inbred Generations

The number of generations that this strain has been inbred at the time the data was curated.

Strain SSLP data

An indication of the number of SSLP markers that have been characterized in this strain. If present, this data is available via the FTP site (SSLPS_ALLELES file) and is also integrated into GenomeScanner for the selection of polymorphic markers between strains.

Strain Characteristics

A textual description of notes obtained from the literature on the following subjects:

  • General - Overall notes or ones that do not fit into any of the following categories.
  • Origin - text describing the origin of the strain or colony.
  • Anatomy - anatomical notes about the strain
  • Behavior - observations on the behavior of the strain
  • Drugs and Chemicals - interactions and responsiveness to various drugs and chemicals
  • Immunology - Immunological notes about the strain
  • Infection - Susceptibility and response to infection
  • Lifespan and Spontaneous Disease - Typical lifespan of this strain, known disease-susceptibilities
  • Physiology and Biochemistry - results pertaining to the physiology or biochemistry of this strain
  • Reproduction - notes on the reproductive success of this strain, litter sizes, etc.

Associated References

References curated by the RGD curation team that contain information pertaining to this strain.

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.
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