• What is Metagene?
• What information do you have on Metagene?
• What other information can I get to via Metagene?
• Detailed Metagene help documents
• Let me use Metagene...

"MetaGene is a tool that allows the researcher to submit sequences to seven gene prediction engines simultaneously to obtain a comprehensive report on sequence features. It is effective in consolidating all predicted features in the sequence into a unifying framework thereby allowing further studies to be conducted such as the identification of apparent classification of gene features via cluster analysis applied to large collections of known genes."

MetaGene users have default choices for each of the nine search engines and for the types of annotation to be carried out. This predetermines the quality of the analysis output. Based on the optimization of all the results, MetaGene can give its own predicted values at optimal threshold, all as a graphical and animated annotation.

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MetaGene allows the researcher to submit sequences to seven gene prediction engines simultaneously to obtain a comprehensive report on sequence features. Genomic sequence data should be submitted to MetaGene in one of a number of accepted formats.

The basic MetaGene interface is shown below:

Each gene prediction engine has its own options that can be set via the MetaGene interface prior to submission. The MetaGene server then submits the supplied sequence to each of the selected prediction tools in batch mode, emailing a reply to the user once the analysis is complete. For more information on the analyses and results, see below.

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The output may have either known genes or predicted genes. For known genes, the general query in RGD can be used to find RGD gene entries. VCMap will help to locate the flanking genes and homologous regions in human and mouse.

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Metagene outputs annotation and analysis of a given sequence query in the form of a window with defined menus. Based on the user-set limits, annotations can be visualized as a line diagram or on the displayed sequence. Visual comparison of the performance of search engines and gene predictions, evaluation of the predictions with known features if available in that region and the summary of statistics leading towards Metagene output can be obtained through different menu options.

The output of Metagene and its interpretation is described on the detailed MetaGene Help page.

Metagene report help here!

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