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Strain Registration

Strain: F344-Tg(NC1-269B17)1Nkg

Symbol: F344-Tg(NC1-269B17)1Nkg
Strain: F344-Tg(NC1-269B17)1
Substrain: Nkg
RGD ID: 8548794
Citation ID: RRID:RGD_8548794
Ontology ID: RS:0003639
Alleles: Casp3
Also Known As: NBRP Rat No: 0621
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: BAC clone NC1-269B17 which containing about 120 kb of ACI/NJcl rat-derived Casp3 (caspase 3) was injected into F344/Jcl embryos. The founder rat was backcrossed into F344/Jcl rat to establish the transgenic strain.
Coat Color: albino
Inbred Generations: N3
Last Known Status: Cryopreserved Sperm






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This transgenic rat possesses one copy of BAC clone. Hemizygous rat expresses higher level of Casp3 protein in adenocarcinoma of the large intestine than that of wild type rat. This transgenic rat is lower susceptible to PhIP-induced ACF (aberrant crypt foci) formation than the wild-type rat 1302502
strain_reproduction This strain is maintained by backcrossing of male transgenic rats into female F344/Jcl. 1302502