Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: WI-Tlr4em1Geh

Symbol: WI-Tlr4em1Geh
Strain: WI-Tlr4em1
Substrain: Geh
RGD ID: 7257663
Citation ID: RRID:RRRC_00694
Ontology ID: RS:0003464
Alleles: Tlr4em1Geh
Variant(s): Tlr4em1Geh-var1
Also Known As: WI-Tlr4em1Geh; WI-Tlr4^[em1Geh]
Type: mutant
Available Source: Rat Resource and Research Center
Origination: University of Pittsburgh
Description: This strain was produced by TALEN mediated 13 bp deletion in Exon 1 in the rat Tlr4 gene; background strain is Crl:WI
Coat Color: white
Last Known Status: Unknown
Research Usage alcohol action, immune system function, septic shock
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8585,161,247 - 85,174,882RGD_MAPPER_PIPELINE
mRatBN7.2580,146,180 - 80,146,192RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0582,587,737 - 82,587,749RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0586,690,670 - 86,704,302RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4583,564,100 - 83,577,735RGD_MAPPER_PIPELINERGSC_v3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Ferguson C, etal., Alcohol. 2013 Dec;47(8):595-9. doi: 10.1016/j.alcohol.2013.09.043. Epub 2013 Oct 11.
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Tlr4em1Geh-var1 chr5 80146180 80146192 ATCCCTGCATAGA - deletion mRatBN7.2
Tlr4em1Geh-var1 chr5 82587737 82587749 ATCCCTGCATAGA - deletion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Overtly normal but fail to respond to challenge with lippopolysaccharide 2292495
strain_characteristics The homozygous knockout animals have no overt phenotype, at least to 4 weeks of age 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-03 WI-Tlr4em1Geh    WI-Tlr4em1Geh    Symbol updated 68687 APPROVED
2014-04-03 WI-Tlr4em1Geh    WI-Tlr4em1Geh    Symbol updated 68687 APPROVED
2014-04-03 WI-Tlr4em1Geh    WI-Tlr4em1Geh    Name updated 68913 APPROVED
2014-04-03 WI-Tlr4em1Geh    WI-Tlr4em1Geh    Name updated 68913 APPROVED
2013-08-28 WI-Tlr4em1Geh    WI-Tlr4em1Geh    Name updated 68913 APPROVED
2013-08-28 WI-Tlr4em1Geh    WI-Tlr4em1Geh    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00694 RGD