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Strain Registration

Strain: KDP/Tky

Symbol: KDP/Tky
Strain: KDP
Substrain: Tky
Full Name: Komeda diabetes-prone rat
RGD ID: 724576
Citation ID: RRID:RGD_724576
Ontology ID: RS:0000433
Alleles: Cblb
Also Known As: NBRP Rat No: 0026; Komeda Diabetes Prone Rat; MDC-02-76
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This is a diabetic-prone substrain of LETL where only diabetic males were used for the backcross.
Coat Color: a, B, C, h
Inbred Generations: F27
Last Known Status: Live Animals; Cryopreserved Embryo
Research Usage Diabetes Obesity; Immunology





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
KDP/TkyRatKDP/Tky  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
KDP/TkyRatblood glucose amount  EXP 634732 RGD 

Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats. Komeda K, etal., Endocr J. 1998 Dec;45(6):737-44. doi: 10.1507/endocrj.45.737.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
5. A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat. Yokoi N, etal., J Clin Invest 1997 Oct 15;100(8):2015-21.
6. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi N, etal., Nat Genet 2002 Aug;31(4):391-4.

Region

Strain QTL Data
Symbol Name Trait
Iddm17 Insulin dependent diabetes mellitus QTL 17 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease These rats develop moderate to severe insulitis within 220 days of age. The cumulative frequency of IDDM was 70% at 120 days of age, and reached 82% within 220 days of age 634732
strain_reproduction These are maintained in heterozygous condition. 625457

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-07 KDP/Tky  Komeda diabetes-prone rat  KDP/Tky  Komeda diabetes-prone rat  Name updated 68913 APPROVED