Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: SR

Symbol: SR
Strain: SR
RGD ID: 70453
Citation ID: RRID:RGD_70453
Ontology ID: RS:0000784
Type: inbred
Available Source: Not Available
Description: Rapp from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b). Also designated R/JR by Rapp (1984), and Dahl R by Mollegard, Copenhagen.
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F54
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Rat Strain List M. Festing Rat Strain List
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta) (Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 1004
strain_characteristics Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta) (Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 634612