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Strain Registration

Strain: FH

Symbol: FH
Strain: FH
RGD ID: 68036
Citation ID: RRID:RGD_68036
Ontology ID: RS:0000316
Alleles: Rab38ru
Type: inbred
Available Source: Not Available
Description: Dodds, 1974 from an outbred stock developed by NRF Maier, University of Michigan, Ann Arbor, from a cross between German brown rats and white Lashley rats (Tschopp and Zucker 1972). Note that other inbred strains have been developed from the same outbred stock (see strains FHH and FHL), which may have different characteristics.
Genetic Markers: a,C,h,r.
Coat Color: Fawn hooded.
Inbred Generations: F33
Last Known Status: Unknown

Substrains
FH/HamSlc
FH/Unc

Mutant Strains
FH/HamSlc




References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Rat Strain List M. Festing Rat Strain List
3. The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain. Oiso N, etal., Mamm Genome 2004 Apr;15(4):307-14.
4. Characterization of the fawn-hooded rat as a model for hemostatic studies. Raymond SL and Dodds WJ, Thromb Diath Haemorrh 1975 Apr 30;33(2):361-9.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Rab38ru-var1 chr1 142182614 142182614 G A point_mutation mRatBN7.2
Rab38ru-var1 chr1 152072764 152072764 G A point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Good reproductive performance (Greenhouse et al 1991). Mild bleeding diathesis caused by autosomal dominant (? see below) gene, which is exacerbated by trauma and surgery and increases with age. Variable platelet aggregation defects and reduced platelet ATP, ATP/ADP ratio, and serotonin content and release (Raymond and Dodds 1975). Humoural immunity and compelment activity normal, but aged animals appear susceptible to infection. There is glomerular sclerosis early in life, with proteinurea as early as 10-12 weeks, which gradually progresses with age. At one year, FH rats have kidneys with lesions like those of 2-year old Sprague Dawley or Wistar rats (Kreisberg and Karnovsky 1978, Dodds 1988). Urizar et al (1984) suggest that the platlet defect and the nephropathy are unrelated, and the latter does not seem to be mediated by immune complexes. Moreover, the nephropathy progresses without imparement of renal function Prieur and Meyers (1984) have shown that the platelet storage pool defect is a pleiotropic effect of the red-eyed dilution gene r, and that both coat colour and the platelet defect are inherited as autosomal recessive (not dominant) characters. Platelets are less reactive to collagen than those of normal rats (Magro et al, 1992). Outbred Nmh:FAWN HOODED rats developed spontaneous hypertension (Rudofsky and Magro 1982). 1004
strain_life_disease Good reproductive performance (Greenhouse et al 1991). Mild bleeding diathesis caused by autosomal dominant (? see below) gene, which is exacerbated by trauma and surgery and increases with age. Variable platelet aggregation defects and reduced platelet ATP, ATP/ADP ratio, and serotonin content and release (Raymond and Dodds 1975). Humoural immunity and compelment activity normal, but aged animals appear susceptible to infection. There is glomerular sclerosis early in life, with proteinurea as early as 10-12 weeks, which gradually progresses with age. At one year, FH rats have kidneys with lesions like those of 2-year old Sprague Dawley or Wistar rats (Kreisberg and Karnovsky 1978, Dodds 1988). Urizar et al (1984) suggest that the platlet defect and the nephropathy are unrelated, and the latter does not seem to be mediated by immune complexes. Moreover, the nephropathy progresses without imparement of renal function Prieur and Meyers (1984) have shown that the platelet storage pool defect is a pleiotropic effect of the red-eyed dilution gene r, and that both coat colour and the platelet defect are inherited as autosomal recessive (not dominant) characters. Platelets are less reactive to collagen than those of normal rats (Magro et al, 1992). Outbred Nmh:FAWN HOODED rats developed spontaneous hypertension (Rudofsky and Magro 1982). 634612