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Strain Registration

Strain: SD-Tg(Rho-S334X)3LavRrrc

Symbol: SD-Tg(Rho-S334X)3LavRrrc
Strain: SD-Tg(Rho-S334X)3
Substrain: LavRrrc
RGD ID: 6482645
Citation ID: RRID:RRRC_00643
Ontology ID: RS:0003242
Also Known As: SD-Tg(S334ter)3LavRrrc; RRRC:00643
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated rhodopsin protein. Submitted to Rat Resource & Research Center
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-08-17)






References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. Morphological alterations in retinal neurons in the S334ter-line3 transgenic rat. Ray A, etal., Cell Tissue Res. 2010 Mar;339(3):481-91. doi: 10.1007/s00441-009-0916-5. Epub 2010 Feb 2.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Rats demonstrate both photoreceptor degeneration and immunodeficiency (background: NIH nude rat). The outer nuclear layer is reduced to one row at the age of 3-4 weeks. The rod photoreceptors do not develop outer segments. 2292495
strain_other Transplantation of human cells to replace demaged or lost photoreceptors or to prevent retinal degeneration without the need of immunosuppression. For experiments, rats can have 1 or 2 copies of transgene, but need to be homozygous nude. The advantage of not having to use immunosuppression means healthier transplant recipients, and healthier transplants. Although the rats need to be housed under protective conditions, they are in general much healthier than immunosuppressed rats. 2292495
strain_other to be retired from RRRC after July 8th 2013 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-17 SD-Tg(Rho-S334X)3LavRrrc    SD-Tg(S334ter)3LavRrrc    Symbol updated 68687 APPROVED
2017-08-17 SD-Tg(Rho-S334X)3LavRrrc    SD-Tg(S334ter)3LavRrrc    Symbol updated 68687 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00643 RGD