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Strain Registration

Strain: LE/BluGill

Symbol: LE/BluGill
Strain: LE/BluGill
RGD ID: 631163
Citation ID: RRID:RGD_631163
Ontology ID: RS:0000436
Type: inbred
Available Source: Not Available
Origination: University of Illinois at Urbana-Champaign
Description: This inbred colony from the University of Illinois at Urbana-Champaign was derived from Long Evans Outbred rats originally purchased from Blue Spruce Farms, Altamont, NY in the Fall of 1982. In order to reduce individual differences, Principal Investigator, Martha U. Gillette, PhD, initiated inbreeding (consecutive brother-sister matings). In March 1993, the colony reached generation #20, defined by the Institute for Animal Laboratory Research (ILAR) as the point during inbreeding at which the strain can officially be considered inbred. This inbred colony continues to be used by Dr. Gillette and her laboratory at the University of Illinois at Urbana-Champaign to research cell, molecular and integrative mechanisms in the brain's circadian clock.
Coat Color: Albino
Inbred Generations: F20
Last Known Status: Unknown





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "LE/BluGill" (RS:0000436)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. Carbon monoxide and nitric oxide: interacting messengers in muscarinic signaling to the brain's circadian clock. Artinian LR, etal., Exp Neurol 2001 Oct;171(2):293-300.
2. Requirement of mammalian Timeless for circadian rhythmicity. Barnes JW, etal., Science 2003 Oct 17;302(5644):439-42.
3. Localization and characterization of nitric oxide synthase in the rat suprachiasmatic nucleus: evidence for a nitrergic plexus in the biological clock. Chen D, etal., J Neurochem 1997 Feb;68(2):855-61.
4. Pituitary adenylyl cyclase-activating peptide: a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock. Chen D, etal., Proc Natl Acad Sci U S A 1999 Nov 9;96(23):13468-73.
5. Role of the M1 receptor in regulating circadian rhythms. Gillette MU, etal., Life Sci 2001 Apr 27;68(22-23):2467-72.
6. Pituitary adenylate cyclase activating peptide (PACAP) in the retinohypothalamic tract: a daytime regulator of the biological clock. Hannibal J, etal., Ann N Y Acad Sci 1998 Dec 11;865:197-206.
7. Pituitary adenylate cyclase-activating peptide (PACAP) in the retinohypothalamic tract: a potential daytime regulator of the biological clock. Hannibal J, etal., J Neurosci 1997 Apr 1;17(7):2637-44.
8. Coupling of muscarinic cholinergic receptors and cGMP in nocturnal regulation of the suprachiasmatic circadian clock. Liu C, etal., J Neurosci 1997 Jan 15;17(2):659-66.
9. PhysGen Strains PhysGen strains
10. RGD Strain RSO annotation pipeline RGD Automated Pipelines
11. Oscillation and light induction of timeless mRNA in the mammalian circadian clock. Tischkau SA, etal., J Neurosci 1999 Jun 15;19(12):RC15.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics 6-9 week animals are used for making coronal hypothalmic slice which has paired suprachiasmatic nucleus (SCN). These brain slices can survive three days with continuous perfusion and can be used to determine the circadian rhythms generated by the endogenous circadian clock. 734507
strain_characteristics 6-9 week animals are used for making coronal hypothalmic slice which has paired suprachiasmatic nucleus (SCN). These brain slices can survive three days with continuous perfusion and can be used to determine the circadian rhythms generated by the endogenous circadian clock. 734508
strain_characteristics 6-9 week animals are used for making coronal hypothalmic slice which has paired suprachiasmatic nucleus (SCN). These brain slices can survive three days with continuous perfusion and can be used to determine the circadian rhythms generated by the endogenous circadian clock. 734509
strain_life_disease The blood pressure of females is 103 mmHg and of males is 109 mmHg. 629526
strain_other The average weight of females is 248g and of males 345g. 629526