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Strain: SD-Foxn1rnuTg(Rho-S334X)3LavRrrc

Symbol: SD-Foxn1rnuTg(Rho-S334X)3LavRrrc
Strain: SD-Foxn1rnuTg(Rho-S334X)3LavRrrc
Substrain: LavRrrc
RGD ID: 626189117
Citation ID: RRID:RRRC_00539
Ontology ID: RS:0005469
Also Known As: RRRC:00539; RD nude; SD-Foxn1^[rnu]Tg(Rho-S334X)3LavRrrc
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: This strain was created by crossing “SD-Tg(Rho*S334X)3Lav, RGD: 1358302,”( also known as, SD-Tg(S334ter)3Lav , homozygous for a mutated mouse rhodopsin transgene Rho S334ter-3) with “NTac:NIH-Foxn1rnu, RGD: 7246928,” (also known as NTac:NIH-Whn (NIH nude) males (foxn1-/-). By selective breeding, all animals of this strain (RRRC#539) are homozygous for the rhodopsin mutation, and homo- or hemizygous for the foxn1 mutation.
Last Known Status: Cryorecovery (as of 2025-09-03)






References

References - curated
# Reference Title Reference Citation
1. Transplanted sheets of human retina and retinal pigment epithelium develop normally in nude rats. Aramant RB and Seiler MJ, Exp Eye Res. 2002 Aug;75(2):115-25. doi: 10.1006/exer.2002.2001.
2. Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Sagdullaev BT, etal., Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1686-95. doi: 10.1167/iovs.02-0615.
3. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. Seiler MJ, etal., Eur J Neurosci. 2010 Feb;31(3):508-20. doi: 10.1111/j.1460-9568.2010.07085.x. Epub 2010 Jan 25.
4. A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression. Seiler MJ, etal., Graefes Arch Clin Exp Ophthalmol. 2014 Jul;252(7):1079-92. doi: 10.1007/s00417-014-2638-y. Epub 2014 May 13.

Region


Additional Information

Database Acc Id Source(s)
RRRC RRRC:00539 RGD