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Strain Registration

Strain: DRH/Seac

Symbol: DRH/Seac
Strain: DRH
Substrain: Seac
RGD ID: 625659
Citation ID: RRID:RGD_625659
Ontology ID: RS:0000249
Also Known As: NBRP Rat No: 0078; MDC-01-71
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Established by inbreeding closed colony of Donryu rats ( purchased from SEAC Yoshitomi, Ltd. Fukuoka, Japan) for more than 20 generations, their diet continously contained a hepatocarcinogen 3
Inbred Generations: 20
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Cancer





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
liver tumorous lesion number
area of individual liver tumorous lesion
area of liver occupied by tumorous lesions as percentage of total liver area
area of liver occupied by fibrotic lesions to total liver area ratio
TUNEL-positive cell number to total cell number ratio
liver ornithine decarboxylase activity
liver tumorous lesion number to liver area ratio
percentage of study population developing liver tumors during a period of time
total surface area of liver occupied by tumorous lesions
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats. Denda A, etal., Cancer Lett 1999 Jun 1;140(1-2):59-67.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
5. Resistance of DRH strain rats to chemical carcinogenesis of liver: genetic analysis of later progression stage. Yan Y, etal., Carcinogenesis 2002 Jan;23(1):189-96.
6. Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats. Zeng ZZ, etal., Cancer Res 2000 Jun 1;60(11):2876-81.

Region

Strain QTL Data
Symbol Name Trait
Hcar4 Hepatocarcinoma resistance QTL 4 liver integrity trait   (VT:0010547)    
Hcar5 Hepatocarcinoma resistance QTL 5 liver integrity trait   (VT:0010547)    
Hcar6 Hepatocarcinoma resistance QTL 6 liver integrity trait   (VT:0010547)    
Hcar7 Hepatocarcinoma resistance QTL 7 liver integrity trait   (VT:0010547)    
Hcar8 Hepatocarcinoma resistance QTL 8 liver integrity trait   (VT:0010547)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These are highly resistant to chemical-induced liver carcinogenesis and have fewer and smaller GST-P (glutathione S-transferase-placental form) than F344 rats. 625382
strain_drgs_chems Rats are highly resistant to chemical induction of hepatocellular carcinoma and preneoplastic lesions 619609
strain_drgs_chems When male rats were treated with N-nitrosodiethylamine and fed a diet containing 3'-Me-DAB, after 8 weeks had less than 4% glutathione S-transferase placental form(GST-P) positive lesions. This suggested the suppression of positive foci in the liver under these conditions. 625658
strain_drgs_chems Relative liver weight of animals injected with N-nitrosodiethylamine(DEN)and given 3'-Me-DAB diet was less than Donryu rats treated the same way. 625658
strain_drgs_chems When male rats were treated with N-nitrosodiethylamine and fed a diet containing 3 625658
strain_drgs_chems Relative liver weight of animals injected with N-nitrosodiethylamine(DEN)and given 3 625658

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-09 DRH/Seac    DRH/Seac    Name updated 68913 APPROVED
2012-05-09 DRH/Seac    DRH/Seac    Name updated 68913 APPROVED