| Note Type |
Note |
Reference |
| strain_anatomy |
Low relative heart weight in 10-week old males (4/23) (Tanase et al 1982). |
1004
|
| strain_anatomy |
Low relative heart weight in 10-week old males (4/23) (Tanase et al 1982). |
61059
|
| strain_anatomy |
Low relative heart weight in 10-week old males (4/23) (Tanase et al 1982). |
634612
|
| strain_drgs_chems |
Long pentobarbitone sleeping time in males (3/10) but short time in females (10/10) (Vieregge et al 1987). High serum ceruloplasmin levels (Stolc 1984). Compared with F344, LEW rats show a much higher preference for several classes of drugs of abuse. This may be associated with lower levels of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Duration of morphine-induced EEG slow-wave bursts and associated behavioural stupor was greater in LEW than F344 rats (Myomichelson and Young, 1993). LEW rats self-administer more morphine and drugs of abuse than F344 rats (Gosnell and Krahn, 1993, Glowa et al, 1994, Ambrosio et al, 1995). Duration of EEG slow-wave bursts and behavioural stupor also longer in LEW than F344 following administration of ethylketocyclazocine, suggesting differences in opioid-related receptor populations between these strains (Mayomichelson and Young, 1993). Cocaine conditioned place preference was greater in LEW than F344 rats (Kosten et al, 1994). Susceptible to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast WKY) (Tanaka et al, 1995). Rats were injected with N-methyl-N-nitrosourea (MNU) at 7 weeks of age; 2 weeks later, the rats were subjected to sustained treatment with 20 ug, 100 ug, 200 ug, or 30 ug of E (estradiol) in silastic capsules for 3 weeks. Treatments with 100 ug, 200 ug, or 30 ug of E resulted in serum levels of E equivalent to those of pregnancy and were highly effective in preventing mammary cancer. |
1004
|
| strain_drgs_chems |
Long pentobarbitone sleeping time in males (3/10) but short time in females (10/10) (Vieregge et al 1987). High serum ceruloplasmin levels (Stolc 1984). Compared with F344, LEW rats show a much higher preference for several classes of drugs of abuse. This may be associated with lower levels of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Duration of morphine-induced EEG slow-wave bursts and associated behavioural stupor was greater in LEW than F344 rats (Myomichelson and Young, 1993). LEW rats self-administer more morphine and drugs of abuse than F344 rats (Gosnell and Krahn, 1993, Glowa et al, 1994, Ambrosio et al, 1995). Duration of EEG slow-wave bursts and behavioural stupor also longer in LEW than F344 following administration of ethylketocyclazocine, suggesting differences in opioid-related receptor populations between these strains (Mayomichelson and Young, 1993). Cocaine conditioned place preference was greater in LEW than F344 rats (Kosten et al, 1994). Susceptible to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast WKY) (Tanaka et al, 1995). Rats were injected with N-methyl-N-nitrosourea (MNU) at 7 weeks of age; 2 weeks later, the rats were subjected to sustained treatment with 20 ug, 100 ug, 200 ug, or 30 ug of E (estradiol) in silastic capsules for 3 weeks. Treatments with 100 ug, 200 ug, or 30 ug of E resulted in serum levels of E equivalent to those of pregnancy and were highly effective in preventing mammary cancer. |
61059
|
| strain_drgs_chems |
Long pentobarbitone sleeping time in males (3/10) but short time in females (10/10) (Vieregge et al 1987). High serum ceruloplasmin levels (Stolc 1984). Compared with F344, LEW rats show a much higher preference for several classes of drugs of abuse. This may be associated with lower levels of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Duration of morphine-induced EEG slow-wave bursts and associated behavioural stupor was greater in LEW than F344 rats (Myomichelson and Young, 1993). LEW rats self-administer more morphine and drugs of abuse than F344 rats (Gosnell and Krahn, 1993, Glowa et al, 1994, Ambrosio et al, 1995). Duration of EEG slow-wave bursts and behavioural stupor also longer in LEW than F344 following administration of ethylketocyclazocine, suggesting differences in opioid-related receptor populations between these strains (Mayomichelson and Young, 1993). Cocaine conditioned place preference was greater in LEW than F344 rats (Kosten et al, 1994). Susceptible to the induction of glandular stomach adenocarcinomas following treatment with catechol (contrast WKY) (Tanaka et al, 1995). Rats were injected with N-methyl-N-nitrosourea (MNU) at 7 weeks of age; 2 weeks later, the rats were subjected to sustained treatment with 20 ug, 100 ug, 200 ug, or 30 ug of E (estradiol) in silastic capsules for 3 weeks. Treatments with 100 ug, 200 ug, or 30 ug of E resulted in serum levels of E equivalent to those of pregnancy and were highly effective in preventing mammary cancer. |
634612
|
| strain_infection |
Young animals susceptible to Borrelia burgdorferi-induced arthritic lesions resembling those found in human Lyme disease (Barthold et al 1988). Susceptible to the induction of encephalitis by coronavirus, with a much longer delay in lymphocyte proliferation following infection than in the resistant BN strain (Imrich et al, 1994). Susceptible (1/4) to ocular infection with herpes simplex virus with death following 4 x 104 plaque forming units (pfu). PVG was relatively resistant (Nicholls et al, 1994). |
1004
|
| strain_infection |
Young animals susceptible to Borrelia burgdorferi-induced arthritic lesions resembling those found in human Lyme disease (Barthold et al 1988). Susceptible to the induction of encephalitis by coronavirus, with a much longer delay in lymphocyte proliferation following infection than in the resistant BN strain (Imrich et al, 1994). Susceptible (1/4) to ocular infection with herpes simplex virus with death following 4 x 104 plaque forming units (pfu). PVG was relatively resistant (Nicholls et al, 1994). |
61059
|
| strain_infection |
Young animals susceptible to Borrelia burgdorferi-induced arthritic lesions resembling those found in human Lyme disease (Barthold et al 1988). Susceptible to the induction of encephalitis by coronavirus, with a much longer delay in lymphocyte proliferation following infection than in the resistant BN strain (Imrich et al, 1994). Susceptible (1/4) to ocular infection with herpes simplex virus with death following 4 x 104 plaque forming units (pfu). PVG was relatively resistant (Nicholls et al, 1994). |
634612
|
| strain_life_disease |
Survival 26% at 2 years (Lindsey et al 1968). In a study involving 305 female and 324 male rats of the LEW/Han substrain, mean lifespan in females was 27.7_5.1 months, in males 32.5_6.6 months. In both sexes the lifespan was mainly determined by the occurrence of neoplasms. Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995). [Immunology] Interferon production in response to polyriboinosinic-polyribocytodilic acid 20-40 fold higher than that observed in six other inbred strains. The effect is due to more than one gene, and is not associated with the MHC (Davis et al 1984). Resident macrophages (ramified microglea) of the central nervous system are not constitutively major histocompatibility complex class-II positive, in contrast with BN (Sedgwick et al, 1993). Mercury (HgCl2) stimulates peritoneal polymorphonuclear leukocytes and macrophages to produce hydrogen peroxide, in contrast with strain BN (Contrino et al, 1992). Resistant to the development of autoimmunity from skin-injected HgCl2 , in contrast to BN (Warfvinge and Larsson, 1994). Poor (5/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). Although DA and LEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Highly susceptible to inflammatory disease due to deficient glucocorticoid counter-regulation of the immune response resulting from deficient corticotropin-releasing hormone responsiveness. Have significantly more benzodiazepine binding sites than F344, though there was no difference in affinities (Smith et al, 1992 see also Oitzl et al, 1995). No differences between LEW and F344 in the sensitivity of target tissues to exogenous glucocorticoids which could be associated with differences in susceptibility to inflammatory disease (Karalis et al, 1995). Short-term sustained treatments with pregnancy levels of E (estradiol) can induce protection against frank mammary cancer. |
1004
|
| strain_life_disease |
Survival 26% at 2 years (Lindsey et al 1968). In a study involving 305 female and 324 male rats of the LEW/Han substrain, mean lifespan in females was 27.7_5.1 months, in males 32.5_6.6 months. In both sexes the lifespan was mainly determined by the occurrence of neoplasms. Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995). [Immunology] Interferon production in response to polyriboinosinic-polyribocytodilic acid 20-40 fold higher than that observed in six other inbred strains. The effect is due to more than one gene, and is not associated with the MHC (Davis et al 1984). Resident macrophages (ramified microglea) of the central nervous system are not constitutively major histocompatibility complex class-II positive, in contrast with BN (Sedgwick et al, 1993). Mercury (HgCl2) stimulates peritoneal polymorphonuclear leukocytes and macrophages to produce hydrogen peroxide, in contrast with strain BN (Contrino et al, 1992). Resistant to the development of autoimmunity from skin-injected HgCl2 , in contrast to BN (Warfvinge and Larsson, 1994). Poor (5/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). Although DA and LEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Highly susceptible to inflammatory disease due to deficient glucocorticoid counter-regulation of the immune response resulting from deficient corticotropin-releasing hormone responsiveness. Have significantly more benzodiazepine binding sites than F344, though there was no difference in affinities (Smith et al, 1992 see also Oitzl et al, 1995). No differences between LEW and F344 in the sensitivity of target tissues to exogenous glucocorticoids which could be associated with differences in susceptibility to inflammatory disease (Karalis et al, 1995). Short-term sustained treatments with pregnancy levels of E (estradiol) can induce protection against frank mammary cancer. |
61059
|
| strain_life_disease |
Survival 26% at 2 years (Lindsey et al 1968). In a study involving 305 female and 324 male rats of the LEW/Han substrain, mean lifespan in females was 27.7_5.1 months, in males 32.5_6.6 months. In both sexes the lifespan was mainly determined by the occurrence of neoplasms. Of the large spectrum of 52 histologically different types of tumours, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumours and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumours of the haemopoietic system (28%) in males (Baum et al, 1995). [Immunology] Interferon production in response to polyriboinosinic-polyribocytodilic acid 20-40 fold higher than that observed in six other inbred strains. The effect is due to more than one gene, and is not associated with the MHC (Davis et al 1984). Resident macrophages (ramified microglea) of the central nervous system are not constitutively major histocompatibility complex class-II positive, in contrast with BN (Sedgwick et al, 1993). Mercury (HgCl2) stimulates peritoneal polymorphonuclear leukocytes and macrophages to produce hydrogen peroxide, in contrast with strain BN (Contrino et al, 1992). Resistant to the development of autoimmunity from skin-injected HgCl2 , in contrast to BN (Warfvinge and Larsson, 1994). Poor (5/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). Although DA and LEW are both highly susceptible to the development of EAE, there are marked differences in the array of myelin epitopes capable of inducing the disease as well as MHC restriction of these epitopes between the two strains (Stepaniak et al, 1995). Highly susceptible to inflammatory disease due to deficient glucocorticoid counter-regulation of the immune response resulting from deficient corticotropin-releasing hormone responsiveness. Have significantly more benzodiazepine binding sites than F344, though there was no difference in affinities (Smith et al, 1992 see also Oitzl et al, 1995). No differences between LEW and F344 in the sensitivity of target tissues to exogenous glucocorticoids which could be associated with differences in susceptibility to inflammatory disease (Karalis et al, 1995). Short-term sustained treatments with pregnancy levels of E (estradiol) can induce protection against frank mammary cancer. |
634612
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| strain_life_disease |
Recovery of cortonary flow rate was more than 60% of its ischemic value which is similar to WIST/Hsd and SS/JrHsdMcwi but less than DA/OlaHsd and BN/NHsdMcwi. |
1342469
|
| strain_phys_biochem |
High fertility. High serum thyroxine, insulin and growth hormone levels (1/5 in each case) (Esber et al 1974). Becomes obese on a high fat diet (rank 2/7)(Schemmel et al 1970). High hepatic metabolism of ethylmorphine in females (3/10) (Page and Vesell 1969). Short gestation period (3/8) (Peters 1986). Low blood pressure (22/23), reaching 119_2.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Liver gangliosides are of the a-type (cf ACI, LEA, & BUF) (Kasai et al 1993). Rapid metaboliser of MPPB (F344 is slow) (Takahara et al 1993). Have substantially lower levels of diurnal and stress related corticosterone levels with higher levels of corticosteroid-binding globulin in plasma, spleen and thymus than F344 rats (Dhabhar et al, 1993). Lower concentrations of cortical and hippocampal 5-HT1A receptors compared with F344 and outbred Spargue-Dalwey rats (Burnet et al, 1994). Hackbarth et al (1981) report on kidney function in this and other strains. Hackbarth et al (1983) report on haematological parameters in relation to several other strains. |
1004
|
| strain_phys_biochem |
High fertility. High serum thyroxine, insulin and growth hormone levels (1/5 in each case) (Esber et al 1974). Becomes obese on a high fat diet (rank 2/7)(Schemmel et al 1970). High hepatic metabolism of ethylmorphine in females (3/10) (Page and Vesell 1969). Short gestation period (3/8) (Peters 1986). Low blood pressure (22/23), reaching 119_2.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Liver gangliosides are of the a-type (cf ACI, LEA, & BUF) (Kasai et al 1993). Rapid metaboliser of MPPB (F344 is slow) (Takahara et al 1993). Have substantially lower levels of diurnal and stress related corticosterone levels with higher levels of corticosteroid-binding globulin in plasma, spleen and thymus than F344 rats (Dhabhar et al, 1993). Lower concentrations of cortical and hippocampal 5-HT1A receptors compared with F344 and outbred Spargue-Dalwey rats (Burnet et al, 1994). Hackbarth et al (1981) report on kidney function in this and other strains. Hackbarth et al (1983) report on haematological parameters in relation to several other strains. |
61059
|
| strain_phys_biochem |
High fertility. High serum thyroxine, insulin and growth hormone levels (1/5 in each case) (Esber et al 1974). Becomes obese on a high fat diet (rank 2/7)(Schemmel et al 1970). High hepatic metabolism of ethylmorphine in females (3/10) (Page and Vesell 1969). Short gestation period (3/8) (Peters 1986). Low blood pressure (22/23), reaching 119_2.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Liver gangliosides are of the a-type (cf ACI, LEA, & BUF) (Kasai et al 1993). Rapid metaboliser of MPPB (F344 is slow) (Takahara et al 1993). Have substantially lower levels of diurnal and stress related corticosterone levels with higher levels of corticosteroid-binding globulin in plasma, spleen and thymus than F344 rats (Dhabhar et al, 1993). Lower concentrations of cortical and hippocampal 5-HT1A receptors compared with F344 and outbred Spargue-Dalwey rats (Burnet et al, 1994). Hackbarth et al (1981) report on kidney function in this and other strains. Hackbarth et al (1983) report on haematological parameters in relation to several other strains. |
634612
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