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Strain Registration

Strain: SD-Gfapem1Mes+/-

Symbol: SD-Gfapem1Mes+/-
Strain: SD-Gfapem1+/-
Substrain: Mes
RGD ID: 598973845
Citation ID: RRID:RGD_598973845
Ontology ID: RS:0005434
Alleles: Gfapem1Mes
Also Known As: SD-Gfapem1Mes; Gfap-R237H KI; SD-Gfap^[em1Mes+/-]
Type: mutant
Available Source: The strain is now deposited at Rat Resource and Research Center
Origination: Waisman Center, University of Wisconsin Madison
Description: The targeted mutation in the rat GFAP gene was based on the severity and frequency of the R239H mutation in human disease. The CRISPR/Cas9 system was used to mediated knockin of point mutation (R237H) to Sprague-Dawley embryos. The current background srain is Crl:CD (SD). This mutant strain serves as a model for Alexander disease. knockins have post-weaning failure to thrive and ~10% mortality by 12 weeks, but afterwards are viable and can breed .
Genetic Status: Heterozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81088,352,987 - 88,361,661RGD_MAPPER_PIPELINE
mRatBN7.21087,852,891 - 87,861,631RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01090,990,762 - 90,999,435RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.01090,763,150 - 90,771,823RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.41092,059,881 - 92,068,555RGD_MAPPER_PIPELINERGSC_v3.4

Mutant Strains
SD-Gfapem1Mes+/- /Rrrc





References

References - curated
# Reference Title Reference Citation
1. Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment. Preprint bioRxiv. Tracy L. Hagemann, Berit Powers, Ni-Hsuan Lin, Ahmed F. Mohamed, Katerina L. Dague, Seth C. Hannah, Curt Mazur, Frank Rigo, Mel B. Feany, Ming-Der Perng, Robert F. Berman, Albee Messing

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-05-12 SD-Gfapem1Mes+/-    SD-Gfapem1Mes    Symbol and/or name change 68913 APPROVED