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Strain Registration

Strain: SD-Tg(Eno2-ATXN3*64Q)16Kakiz

Symbol: SD-Tg(Eno2-ATXN3*64Q)16Kakiz
Strain: SD-Tg(Eno2-ATXN3*64Q)16
Substrain: Kakiz
RGD ID: 4140410
Citation ID: RRID:RGD_4140410
Ontology ID: RS:0002452
Also Known As: NBRP Rat No: 0598;NSE-Q64C(L16)
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Background strain is Slc:SD.
Last Known Status: Cryopreserved Sperm
Research Usage Neurobiology






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This transgenic strain contains human ATXN3 (MJD1, polyQ repeat 64) gene fragment driven by rat Eno2 (NSE: neuron specific enolase) promoter. Transgene ATXN3*64Q is the construct containing of C-terminal part and polyglutamine part of human ATXN3, but not of N-terminal part. Aggregation of ATXN3*64Q polygultamine leads to ataxia. Line 16 is more likely to develop ataxia than Line 29. 1302502
strain_reproduction Maintained by crossing between Tg heterozygous and wild rats. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-29 SD-Tg(Eno2-ATXN3*64Q)16Kakiz    SD-Tg(Eno2-ATXN3*64Q)16Kakiz    Name updated 68913 APPROVED
2012-05-29 SD-Tg(Eno2-ATXN3*64Q)16Kakiz    SD-Tg(Eno2-ATXN3*64Q)16Kakiz    Name updated 68913 APPROVED