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Strain: TT/Sgn

Symbol: TT/Sgn
Strain: TT
Substrain: Sgn
RGD ID: 4139890
Citation ID: RRID:RGD_4139890
Ontology ID: RS:0002441
Alleles: Fkbp6
Also Known As: NBRP Rat No: 0597
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Rats with bilateral small testes were found in a Wistar-Imamichi derived inbred strain in 1986 at the Institute for Animal Reproduction. TT was established from these mutant rats as known as aspermia rats.
Coat Color: Albino
Inbred Generations: F20
Last Known Status: Cryopreserved Sperm
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,318,251 - 21,390,350RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01224,365,941 - 24,438,088RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01226,363,264 - 26,435,311RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41222,474,002 - 22,544,784RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Crackower MA, etal., Science. 2003 May 23;300(5623):1291-5.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Their phenotype is caused by autosomal recessive mutation, as (aspermia). Homozygous mutant males show arrest of spermatogenesis, mainly at the pachytene stage. Testis weight of mutants was about one-third of that of normal males. A large basophilic inclusion-like body existed in the cytoplasm of late pachytene spermatocytes. The result of spermatogonial transplantation suggested that defective spermatogenesis is caused by defects of both germ cell itself and somatic cell component such as blood-testis barrier. Heterozygous males and homozygous females are fertile. aswas revealed to be caused by a genomic deletion including exon 8 of Fkbp6 gene on rat chromosome 12. 1582485
strain_reproduction Maintained by crossing between heterozygous males and homozygous or heterozygous females. 1582485

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-29 TT/Sgn    TT/Sgn    Name updated 68913 APPROVED
2012-05-29 TT/Sgn    TT/Sgn    Name updated 68913 APPROVED