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Strain: F344-Phf24em2Kyo

Symbol: F344-Phf24em2Kyo
Strain: F344-Phf24em2
Substrain: Kyo
RGD ID: 38676450
Citation ID: RRID:RGD_38676450
Ontology ID: RS:0004885
Also Known As: Phf24-null rat; F344-KIAA1045em2Kyo; NBRP Rat No: 0749; KIAA1045-KO, Δ392; F344-Phf24^[em2Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: In 2013, F344/Stm female rat deleted 392b (delta392) of KIAA1045 (Phf24) was generated by Platinum TALEN methods. Although spontaneous GTCS is not observed, seizure susceptibility is increased and kindling induced by PTZ is promoted. In addition, locomotor activity is increased, disturbed behavior and spacial memory are decreased, and emotional behavior is increased due to unpleasant stimulation.
Coat Color: albino
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2021-07-01)





Disease Annotations     Click to see Annotation Detail View
epilepsy  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats. Serikawa T, etal., Behav Brain Res. 2019 Sep 2;369:111922. doi: 10.1016/j.bbr.2019.111922. Epub 2019 Apr 27.

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