Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: F344-Hcn1em1Kyo

Symbol: F344-Hcn1em1Kyo
Strain: F344-Hcn1em1
Substrain: Kyo
RGD ID: 38676253
Citation ID: RRID:RGD_38676253
Ontology ID: RS:0004898
Alleles: Hcn1em1Kyo
Variant(s): Hcn1em1Kyo-var1
Also Known As: NBRP Rat No: 0821; Hcn1 KO (Line84); F344-Hcn1^[em1Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 7-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein.
Coat Color: white
Last Known Status: Cryopreserved Sperm (as of 2020-09-16)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8251,531,189 - 51,531,195RGD_MAPPER_PIPELINE
mRatBN7.2249,798,369 - 49,798,375RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0250,399,472 - 50,399,478RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0268,473,431 - 68,874,494RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4249,525,949 - 49,939,066RGD_MAPPER_PIPELINERGSC_v3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Loss of HCN1 subunits causes absence epilepsy in rats. Nishitani A, etal., Brain Res. 2019 Mar 1;1706:209-217. doi: 10.1016/j.brainres.2018.11.004. Epub 2018 Nov 5.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Hcn1em1Kyo-var1 chr2 51531189 51531195 ACAGTAT - deletion GRCr8
Hcn1em1Kyo-var1 chr2 49798369 49798375 ACAGTAT - deletion mRatBN7.2
Hcn1em1Kyo-var1 chr2 50399472 50399478 ACAGTAT - deletion Rnor_6.0

Additional Information