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Strain Registration

Strain: F344-Hcn1em3Kyo

Symbol: F344-Hcn1em3Kyo
Strain: F344-Hcn1em3
Substrain: Kyo
RGD ID: 38676250
Citation ID: RRID:RGD_38676250
Ontology ID: RS:0004896
Also Known As: NBRP Rat No: 0819; Hcn1 KO (Line77); F344-Hcn1^[em3Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: TALEN (Left:ttcagＡＡＴＧＡＴＴＣＡＴＧＧＧ, Right:ＡＣＧＣＡＣＴＣＴＴＣＡＡＡＧＣＴＡ）targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 13-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein.
Coat Color: white
Last Known Status: Cryopreserved Sperm (as of 2020-09-16)






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region


Additional Information