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Strain Registration

Strain: WKY-Col4a5em2Matsu

Symbol: WKY-Col4a5em2Matsu
Strain: WKY-Col4a5em2
Substrain: Matsu
RGD ID: 329845599
Citation ID: RRID:RGD_329845599
Ontology ID: RS:0005269
Alleles: Col4a5em2Matsu
Also Known As: NBRP Rat No: 0963; col4a15aa stop; WKY-Col4a5^[em2Matsu]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Division of Molecular Genetics, Shigei Medical Research Institute, 2117 Yamada, Minami-ku, Okayama, 701-0202, Japan
Description: Genome editing was performed using the rGONAD method to produce three different lines of KO rats due to three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em2 mutant carries a premature stop coden after 15 amino acids due to insertion of a 42bp stop codon. Col4α5 em2 rats have urinary protein and hematuria from early on, and males begin to die at 18 weeks of age and all die by 28 weeks of age.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X109,907,251 - 110,111,214RGD_MAPPER_PIPELINE
mRatBN7.2X105,118,762 - 105,322,699RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X112,769,595 - 112,983,720RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0X111,226,503 - 111,437,171RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4X36,918,697 - 37,130,659RGD_MAPPER_PIPELINERGSC_v3.4





Disease Annotations     Click to see Annotation Detail View
proteinuria  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Creation of X-linked Alport syndrome rat model with Col4a5 deficiency. Namba M, etal., Sci Rep. 2021 Oct 21;11(1):20836. doi: 10.1038/s41598-021-00354-y.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region


Additional Information