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Strain Registration

Strain: W;WIAR-Izumo1em1Osb

Symbol: W;WIAR-Izumo1em1Osb
Strain: W;WIAR-Izumo1em1
Substrain: Osb
RGD ID: 329845586
Citation ID: RRID:RGD_329845586
Ontology ID: RS:0005267
Alleles: Izumo1em1Osb
Also Known As: NBRP Rat No: 0862; W;WIAR-Izumo1^[em1Osb]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Osaka University
Description: Izumo1 KO strain was established by CRISPR/Cas9 system using inbred WIAR (RGD:2304222) (SLC, Inc.). sgRNA:GGTGGCTGCAATAAAGACTT, PAM sequence：TGG. A 7-bp deletion（CTTTGGA）after start codon (Met) in exon2 of Izumo1 gene was detected. After establishment of WIAR background KO rats, this strain was mated with Slc:Wistar (RGD:2314928), hence this mutant is in mix background.Izumo1-deficient male rats are infertile. In female rats, no specific phenotype is observed.
Coat Color: albino
Last Known Status: Cryopreserved Sperm (as of 2023-12-28)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,090,817 - 96,096,893RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01101,603,222 - 101,608,977RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01102,682,319 - 102,682,325RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4196,090,118 - 96,095,872RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Matsumura T, etal., Front Cell Dev Biol. 2022 Jan 12;9:810118. doi: 10.3389/fcell.2021.810118. eCollection 2021.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Izumo1em1Osb-var1 chr1 102682319 102682325 CTTTGGA - deletion Rnor_5.0

Additional Information