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Strain: F344-Kcnn2Trdk/Kyo

Symbol: F344-Kcnn2Trdk/Kyo
Strain: F344-Kcnn2Trdk
Substrain: Kyo
Full Name: Tremor dominant Kyoto
RGD ID: 2314368
Citation ID: RRID:RGD_2314368
Ontology ID: RS:0001881
Alleles: Kcnn2Trdk
Variant(s): Kcnn2Trdk-var1
Also Known As: F344-Trdk/Kyo;NBRP Rat No: 0567; F344-Trdk/Kyo; F344-Trdk/Kyo; F344-Kcnn2^[Trdk]/Kyo
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: The University of Tokyo, The Institute of Medical Science
Description: Tremor dominant Kyoto (Trdk) mutation is an autosomal dominant mutation that appeared in 2008 in a stock of F344/NSlc rats that had been mutagenized with N-ethyl-N-nitrosourea (ENU) (Mashimo et al., 2008). Rats heterozygous for Trdk (Trdk/+) exhibited tremor behavior that was evident around weaning. To remove latent ENU-induced mutations, the laboratory established an F344-Trdk/+ congenic strain by nine rounds of backcrossing. Using positional candidate approach, Trdk mutation was identified as a missense substitution (c. 866 T > A, p. I289N) in Kcnn2.
Genetic Status: Heterozygous
Coat Color: Albino
Last Known Status: Cryopreserved Sperm (as of 2021-07-15)
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81840,338,434 - 40,338,434RGD_MAPPER_PIPELINE
mRatBN7.21838,151,735 - 38,151,735RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01839,372,884 - 39,372,884RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.01838,822,146 - 38,864,110RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.41839,560,962 - 39,705,037RGD_MAPPER_PIPELINERGSC_v3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
tremors  (IMP)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel. Kuramoto T, etal., Brain Res. 2017 Dec 1;1676:38-45. doi: 10.1016/j.brainres.2017.09.012. Epub 2017 Sep 13.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Kcnn2Trdk-var1 chr18 40338434 40338434 T A point_mutation GRCr8
Kcnn2Trdk-var1 chr18 38151735 38151735 T A point_mutation mRatBN7.2
Kcnn2Trdk-var1 chr18 39372884 39372884 T A point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_reproduction This mutant rats are maintained by backcorssing with F344/NSlc. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-29 F344-Kcnn2Trdk/Kyo  Tremor dominant Kyoto  F344-Trdk/Kyo  Tremor dominant Kyoto  Symbol and/or name change 68913 APPROVED