Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: W-Tg(Gnrh1-EGFP)Nphy

Symbol: W-Tg(Gnrh1-EGFP)Nphy
Strain: W-Tg(Gnrh1-EGFP)
Substrain: Nphy
RGD ID: 2306047
Citation ID: RRID:RGD_2306047
Ontology ID: RS:0002230
Alleles: Gnrh1
Also Known As: Wistar-Tg(Gnrh1-EGFP)Nphy; NBRP Rat No: 0469
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This transgenic strain contains the enhanced green fluorescent protein (EGFP) gene driven by gonadotropin-releasing hormone 1 (Gnrh1) promoter. EGFP fluorescence is observed only in Gnrh1-immunoreactive neurons, approximately one third of which has strong EGFP fluorescence.
Coat Color: Albino
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm






References

References - curated
# Reference Title Reference Citation
1. Characterization of voltage-gated calcium currents in gonadotropin-releasing hormone neurons tagged with green fluorescent protein in rats. Kato M, etal., Endocrinology. 2003 Nov;144(11):5118-25. Epub 2003 Aug 13.
2. The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones. Kato M, etal., J Physiol. 2006 Jul 15;574(Pt 2):431-42. Epub 2006 Apr 20.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_reproduction Since high inbred generations reduce breeding performance, crossing to wild type is necessary once in a while. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-18 W-Tg(Gnrh1-EGFP)Nphy    W-Tg(Gnrh1-EGFP)Nphy    Name updated 68913 APPROVED
2012-05-18 W-Tg(Gnrh1-EGFP)Nphy    W-Tg(Gnrh1-EGFP)Nphy    Name updated 68913 APPROVED