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Strain Registration

Strain: KCI/Kyo

Symbol: KCI/Kyo
Strain: KCI
Substrain: Kyo
RGD ID: 2306022
Citation ID: RRID:RGD_2306022
Ontology ID: RS:0002025
Alleles: Pcdh15
Also Known As: Kyoto circling rat; MCI; NBRP Rat No: 0440
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Rats showing abnormal behaviors characterized by constant circling movements were found in the F3 generation of Crl:CD(SD) rats purchased from Charles River Laboratory Japan in 2003.
Coat Color: Albino
Inbred Generations: F3
Last Known Status: Cryopreserved Sperm
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,997,094 - 15,496,446RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02014,952,213 - 15,334,745RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02017,138,580 - 19,021,206RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42014,507,804 - 15,240,479RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
Deafness  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Characterization of the Kyoto circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene. Naoi K, etal., Exp Anim. 2009 Jan;58(1):1-10.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other The mutation on the kci allele is a nonsense mutation and is predicted to result in truncated Pcdh15 protein at the 9th domain of extracellular cadherin domains. 1302502
strain_reproduction Heterozygous female and homozygous male are mated. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-18 KCI/Kyo    KCI/Kyo    Name updated 68913 APPROVED
2012-05-18 KCI/Kyo    KCI/Kyo    Name updated 68913 APPROVED