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Strain Registration

Strain: HAS.LAS-(D2Rat53-D2Rat138)/Rar

Symbol: HAS.LAS-(D2Rat53-D2Rat138)/Rar
Strain: HAS.LAS-(D2Rat53-D2Rat138)
Substrain: Rar
RGD ID: 1641861
Citation ID: RRID:RRRC_00729
Ontology ID: RS:0001328
Also Known As: IHAS.ILAS-Lorr2r; IHAS.ILAS-Lorr2r; HAS.LAS-(D2Rat38-D2Rat69); HAS.LAS-(D2Rat38-D2Rat69); HAS.LAS-(D2Rat53-D2Rat138)/Rar
Type: congenic
Available Source: Rat Resource and Research Center
Origination: Department of Pharmaceutical Sciences, University of Colorado at Denver, Denver, Colorado
Description: HAS1 (RGD:1578700) and LAS1(RGD:1578696) rats were reciprocally mated to produce an F1 generation. Congenics were bred by backcrossing F1 male to HAS1 and the offsprings were genotyped,
Coat Color: black/white hooded
Last Known Status: Cryopreserved Sperm (as of 2019-02-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82198,834,824 - 223,841,096RGD_MAPPER_PIPELINE
mRatBN7.22196,146,703 - 221,167,075RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02211,301,116 - 237,742,948RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.02230,770,662 - 256,283,467RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.42204,077,549 - 230,157,845RGD_MAPPER_PIPELINERGSC_v3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. Quantitative trait Loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. Radcliffe RA, etal., Alcohol Clin Exp Res 2004 Dec;28(12):1796-804.
3. Confirmation of quantitative trait loci for ethanol sensitivity and neurotensin receptor density in crosses derived from the inbred high and low alcohol sensitive selectively bred rat lines. Radcliffe RA, etal., Psychopharmacology (Berl). 2006 Oct;188(3):343-54. Epub 2006 Sep 5.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D2Rat53)
Rat AssemblyChrPosition (strand)Source
GRCr82198,834,824 - 198,834,962 (+)Marker Load Pipeline
mRatBN7.22196,146,703 - 196,146,841 (+)MAPPER
Rnor_6.02211,301,116 - 211,301,253NCBI
Rnor_5.02230,770,662 - 230,770,799UniSTS
RGSC_v3.42204,077,550 - 204,077,687UniSTS
RGSC_v3.42204,077,549 - 204,077,687RGD
Celera2188,792,528 - 188,792,665UniSTS
RGSC_v3.12204,040,304 - 204,040,441RGD
RH 3.4 Map21395.3UniSTS
RH 3.4 Map21395.3RGD
SHRSP x BN Map275.1598RGD
SHRSP x BN Map275.1598UniSTS
Cytogenetic Map2q34UniSTS

Flank 2 / 1 (D2Rat138)
Rat AssemblyChrPosition (strand)Source
GRCr82223,840,857 - 223,841,096 (+)Marker Load Pipeline
mRatBN7.22221,166,836 - 221,167,075 (+)MAPPER
Rnor_6.02237,742,710 - 237,742,948NCBI
Rnor_5.02256,283,229 - 256,283,467UniSTS
RGSC_v3.42230,157,606 - 230,157,845RGD
RGSC_v3.42230,157,607 - 230,157,845UniSTS
Celera2213,402,898 - 213,403,136UniSTS
RGSC_v3.12230,144,347 - 230,144,585RGD
RH 3.4 Map21551.3RGD
RH 3.4 Map21551.3UniSTS
RH 2.0 Map21111.7RGD
SHRSP x BN Map293.1498RGD
FHH x ACI Map2106.2698RGD
Cytogenetic Map2q43UniSTS
Strain QTL Data
Symbol Name Trait
Alcrsp17 Alcohol response QTL 17 response to alcohol trait   (VT:0010489)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics LAS allele was dominant 1600610
strain_characteristics The congenic shows reduced acute alcohol sensitivity compared to the background strain (IHAS1), but only in females, not males. 2292495
strain_other The duration of loss of righting reflex was less in females than in males and blood ethanol concentration was greater in females 1600610
strain_other A region of ~23Mb (min) to 86Mb (max) on chromosome 2 from the strain ILAS1 (Inbred Low Alcohol Sensitivity, replicate 1) was introgressed onto the IHAS1 background. Coordinates are: Outer marker, proximal: 204.1Mb (D2Rat53) Inner marker, proximal: 207.4Mb (D2Rat238) Inner marker, distal: 230.0Mb (D2Rat138) Outer marker, distal: None 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-03 HAS.LAS-(D2Rat53-D2Rat138)/Rar    HAS.LAS-(D2Rat38-D2Rat69)    Symbol updated 68687 APPROVED
2014-11-03 HAS.LAS-(D2Rat53-D2Rat138)/Rar    HAS.LAS-(D2Rat38-D2Rat69)    Name updated 68913 APPROVED
2014-11-03 HAS.LAS-(D2Rat53-D2Rat138)/Rar    HAS.LAS-(D2Rat38-D2Rat69)    Symbol updated 68687 APPROVED
2014-11-03 HAS.LAS-(D2Rat53-D2Rat138)/Rar    HAS.LAS-(D2Rat38-D2Rat69)    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00729 RGD