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Strain Registration

Strain: SS-Sod3m1Mcwi

Symbol: SS-Sod3m1Mcwi
Strain: SS-Sod3m1
Substrain: Mcwi
RGD ID: 1599758
Citation ID: RRID:RRRC_00415
Ontology ID: RS:0001480
Alleles: Sod3m1Mcwi
Also Known As: SS-Sod3m1Mcwi; SOD3E124D Rat; SS-Sod3^[m1Mcwi]
Type: mutant
Available Source: Rat Resource and Research Center
Origination: PhysGen
Description: Male founders were injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups were genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. The E124D mutation was generated from the codon change GAG/GAT.
Last Known Status: Cryopreserved Sperm (as of 2021-11-03)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21458,610,104 - 58,615,845RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01460,958,583 - 60,971,143RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01461,071,304 - 61,083,776RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41463,381,447 - 63,387,180RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
body weight
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
body length, nose to tail
body length, nose to rump
kidney weight
left kidney wet weight
liver weight
lung weight
lung weight to body weight ratio
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
left atrium weight
right atrium weight
serum total cholesterol level
total white blood cell count
serum total bilirubin level
tibia length
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
heart left ventricle weight to body weight ratio
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
single kidney wet weight to body weight ratio
liver weight to body weight ratio
serum total protein level
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
heart left ventricle weight
heart right ventricle weight
heart right ventricle weight to body weight ratio
serum globulin level
heart left ventricle weight to tibia length ratio
heart left atrium weight to body weight ratio
heart right atrium weight to body weight ratio
liver weight to tibia length ratio
lung weight to tibia length ratio
single kidney weight to tibia length ratio
heart right ventricle weight to tibia length ratio
fully muscularized arterioles to total arterioles ratio
non-muscularized arterioles to total arterioles ratio
heart right atrium weight to left atrium weight ratio
heart right atrium weight to tibia length ratio
heart left atrium weight to tibia length ratio
heart right ventricle weight to left ventricle plus septum weight ratio
right ventricular end-systolic blood pressure
mean aortic pressure

References

References - curated
# Reference Title Reference Citation
1. Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. Beyer AM, etal., Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.
2. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Guo H, etal., Free Radic Biol Med. 2020 May 20;152:787-796. doi: 10.1016/j.freeradbiomed.2020.01.023. Epub 2020 Jan 21.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. PhysGen Strains PhysGen strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Xu D, etal., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-21 SS-Sod3m1Mcwi    SS-Sod3m1Mcwi    Symbol updated 68687 APPROVED
2014-03-21 SS-Sod3m1Mcwi    SS-Sod3m1Mcwi    Symbol updated 68687 APPROVED
2014-03-21 SS-Sod3m1Mcwi    SS-Sod3m1Mcwi    Name updated 68913 APPROVED
2014-03-21 SS-Sod3m1Mcwi    SS-Sod3m1Mcwi    Name updated 68913 APPROVED
2012-04-19 SS-Sod3m1Mcwi    SS-Sod3m1Mcwi    Name updated 68913 APPROVED
2012-04-19 SS-Sod3m1Mcwi    SS-Sod3m1Mcwi    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00415 RGD