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Strain: FHH-Ghsrm1Mcwi

Symbol: FHH-Ghsrm1Mcwi
Strain: FHH-Ghsrm1
Substrain: Mcwi
RGD ID: 1579683
Citation ID: RRID:RRRC_00405
Ontology ID: RS:0001119
Alleles: Ghsrm1Mcwi
Also Known As: FHH-Ghsrm1Mcwi; FHH-Ghsr^[m1Mcwi]
Type: mutant
Available Source: Rat Resource and Research Center
Origination: PhysGen
Description: Male founders are injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups are genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. codon CAG/TAG mutation is generated which changes the AA Q343Stop.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22110,268,489 - 110,271,865RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02113,065,953 - 113,071,265RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02132,784,207 - 132,789,319RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42113,269,623 - 113,272,999RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. Bülbül M, etal., J Gastroenterol. 2011 Apr;46(4):469-78. doi: 10.1007/s00535-010-0366-6. Epub 2011 Jan 22.
2. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Clifford PS, etal., Addict Biol. 2012 Nov;17(6):956-63. doi: 10.1111/j.1369-1600.2011.00339.x. Epub 2011 Jul 25.
3. Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food. MacKay H, etal., Physiol Behav. 2016 Sep 1;163:88-96. doi: 10.1016/j.physbeh.2016.04.048. Epub 2016 Apr 27.
4. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
5. PhysGen Strains PhysGen strains
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-21 FHH-Ghsrm1Mcwi    FHH-Ghsrm1Mcwi    Symbol updated 68687 APPROVED
2014-03-21 FHH-Ghsrm1Mcwi    FHH-Ghsrm1Mcwi    Symbol updated 68687 APPROVED
2014-03-21 FHH-Ghsrm1Mcwi    FHH-Ghsrm1Mcwi    Name updated 68913 APPROVED
2014-03-21 FHH-Ghsrm1Mcwi    FHH-Ghsrm1Mcwi    Name updated 68913 APPROVED
2012-04-17 FHH-Ghsrm1Mcwi    FHH-Ghsrm1Mcwi    Name updated 68913 APPROVED
2012-04-17 FHH-Ghsrm1Mcwi    FHH-Ghsrm1Mcwi    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00405 RGD