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Strain Registration

Strain: LEW-Tg(HLA-B*2705,B2M)21-4HTrg

Symbol: LEW-Tg(HLA-B*2705,B2M)21-4HTrg
Strain: LEW-Tg(HLA-B*2705,B2M)21-4H
Substrain: Trg
RGD ID: 14695548
Citation ID: RRID:RRRC_00622
Ontology ID: RS:0004744
Alleles: HLA-B;   B2M
Also Known As: L21-4H
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 150 copies of HLA-B*2705 and 90 copies of human beta-2-microglobulin gene. The transgenic strain was transferred from Dr. Joel Taurog, University of Texas Southwestern Medical School in Dallas to the Rat Resource and Research Center .
Coat Color: Albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm; Cryorecovery (as of 2019-07-08)






References

References - curated
# Reference Title Reference Citation
1. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Hammer RE, etal., Cell. 1990 Nov 30;63(5):1099-112.
2. Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression. Taurog JD, etal., J Immunol. 1993 May 1;150(9):4168-78.

Region


Additional Information

Database Acc Id Source(s)
RRRC RRRC:00622 RGD