Strain Report - Rat Genome Database

Name: SHR/NCrl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Strain Registration

General

Strain: SHR/NCrl
Symbol:	SHR/NCrl
Strain:	SHR
Substrain:	NCrl
RGD ID:	1357994
Citation ID:	RRID:RGD_1357994
Ontology ID:	RS:0000730
Also Known As:	MDC-03-01; SHR/NCrlBR; SHR (CRiv)
Type:	inbred
Available Source:	Charles River Laboratories
Origination:	Charles River Laboratories
Description:	To Charles River from NIH in 1973 at F32. To N 1966 at F13 from Okamoto. Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure; brother-sister mating with continued selection for spontaneous hypertension.
Coat Color:	Albino
Inbred Generations:	F49+
Last Known Status:	Live Animals (as of 2020-01-23)

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Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "SHR/NCrl" (RS:0000730)

Rat Strains:

SHR/NCrl

Clinical Measurements:

Experimental Conditions:

Measurement Methods:

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

plasma total cholesterol level

serum urea nitrogen level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

liver cholesterol level

brain cholesterol level

brain phytosterol level

brain campesterol level

brain sitosterol level

liver sitosterol level

liver campesterol level

liver phytosterol level

plasma sitosterol level

plasma campesterol level

plasma phytosterol level

serum globulin level

References

References - curated

#	Reference Title	Reference Citation
1.	Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity.	Alfazema N, etal., Hypertension. 2019 Sep;74(3):687-696. doi: 10.1161/HYPERTENSIONAHA.118.12409. Epub 2019 Jul 22.
2.	Angiotensinogen messenger RNA stabilization by angiotensin II.	Klett CP, etal., J Hypertens Suppl 1996 Dec;14(5):S25-36.
3.	NIH Rat Strain Data	NIH Rat Strain Data
4.	Strains registered by Charles River Laboratories International, Inc.	Personal communication with Charles River Laboratories
5.	PhysGen Strains	PhysGen strains
6.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
7.	SNP and haplotype mapping for genetic analysis in the rat.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8.	The spontaneously hypertensive rat model of ADHD - The importance of selecting the appropriate reference strain.	Sagvolden T, etal., Neuropharmacology. 2009 Aug 19.

Region

Strain Samples in RGD with Damaging Variants (Polyphen)


Assembly	Sample
mRatBN7.2	SHR/NCrl (2021)	View Damaging Variants

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	the La Jolla colony of SHR rats exhibit a G -> C point mutation at position 1684 of the angiotensinogen gene which appears to affect the secondary structure of the mRNA and strengthen its interaction with a 12 kDa mRNA-stabilizing protein in response to stimulation by angioensin II	1358960
strain_life_disease	The blood pressure of females is 145 mmHg and of males is 154 mmHg.	629526
strain_other	The average weight of females is 164g and of males 279g.	629526

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-12	SHR/NCrl		SHR/NCrl		Name updated	68913	APPROVED
2013-08-12	SHR/NCrl		SHR/NCrl		Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SHR/NCrl

Related Phenotype Data for Term "SHR/NCrl" (RS:0000730)