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Strain Registration

Strain: LEC/Tj

Symbol: LEC/Tj
Strain: LEC
Substrain: Tj
RGD ID: 1302721
Citation ID: RRID:RGD_1302721
Ontology ID: RS:0000448
Alleles: Atp7bhts
Also Known As: NBRP Rat No: 0051
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Found in Long Evans strain at Kobe University > Inbreeding at Hokkaido University > Otsuka Pharmaceutical Co. > The University of Tokushima 1989
Inbred Generations: F45
Last Known Status: Cryopreserved Embryo
Research Usage Cancer
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,952,286 - 70,024,404RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01674,865,516 - 74,944,935RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01674,495,179 - 74,575,822RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41674,607,988 - 74,680,080RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats. Kose H, etal., Genomics. 2007 Jun;89(6):673-7. doi: 10.1016/j.ygeno.2007.03.001. Epub 2007 Apr 16.
2. Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats. Minami T, etal., Jpn J Cancer Res 2001 Aug;92(8):841-7.
3. Point mutation of aldehyde dehydrogenase-2 gene in mutant strains of Long-Evans rats. Nakajima M, etal., Alcohol Alcohol 1994;29 Suppl 1:39-43.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats. Tsuchigauchi T, etal., J Med Invest. 2009 Aug;56(3-4):93-8.

Region

Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
Rnor_5.0 LEC/Tj (KyushuU) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Resistant to ENU-induced transplacental carcinogenesis 2316901
strain_life_disease Hepatitis, jaundice , a defect of T cell maturation 1302502
strain_reproduction Good breeding performance 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-08 LEC/Tj    LEC/Tj    Name updated 68913 APPROVED
2012-05-08 LEC/Tj    LEC/Tj    Name updated 68913 APPROVED