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Strain Registration

Strain: SER/Kyo

Symbol: SER/Kyo
Strain: SER
Substrain: Kyo
Full Name: spontaneously epileptic rat
RGD ID: 1302695
Citation ID: RRID:RGD_1302695
Ontology ID: RS:0000711
Alleles: Aspa;   Atrn
Also Known As: MDC-02-21; NBRP Rat No: 0012
Type: segregating_inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Spontaneously Epileptic Rat was developed as a double mutant by Serikawa by crossing zi rats (derived from SD), carrying an autosomal recessive attractin mutation with trm rats (derived from Kyo:Wistar), carrying a genomic deletion comprising Aspartate Ac
Coat Color: Albino
Inbred Generations: F59
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs. Ji-qun C, etal., Epilepsia. 2005 Sep;46(9):1362-70. doi: 10.1111/j.1528-1167.2005.29604.x.
2. Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. Kitada K, etal., J Neurochem 2000 Jun;74(6):2512-9.
3. Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system. Kuramoto T, etal., Proc Natl Acad Sci U S A 2001 Jan 16;98(2):559-64.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7. Epileptic seizures in rats homozygous for two mutations, zitter and tremor. Serikawa T and Yamada J, J Hered 1986 Nov-Dec;77(6):441-4.
8. Voltage-dependent Calcium Channel Abnormalities in Hippocampal CA3 Neurons of Spontaneously Epileptic Rats. Yan HD, etal., Epilepsia. 2007 Feb 22;.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics In the rat, zitter (zi) and tremor (tm) are autosomal recessive mutations that in homozygotes caused curled whisker hair, and tremor when the animals move. In both mutant types, the presence of many vacuoles gives the central nervous system a spongy appearance. In animals homozygous for both mutations, an epileptic seizure frequently and spontaneously occurred from 7 or 8 weeks of age. 1302445
strain_life_disease Epileptic seizures were due to the enhancement of calcium ion influx in the hippocampal CA3 neurons induced by enhanced voltage-dependent calcium channels 1600256
strain_other 8 bp deletion of Atrn gene for zi allele, genomic deletion of Aspa gene for tm allele. 1302445
strain_reproduction Maintained in homozygous zi allele and heterozygous tm allele. 1302445