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Strain Registration

Strain: RCS/Kyo

Symbol: RCS/Kyo
Strain: RCS
Substrain: Kyo
Full Name: royal college of surgeons rat
RGD ID: 1302660
Citation ID: RRID:RGD_1302660
Ontology ID: RS:0000659
Alleles: Mertkrdy
Also Known As: NBRP Rat No: 0011; MDC-02-19
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Department of Ophthalmology & Visual Sciences, Kyoto University
Description: From Department of Ophthalmology & Visual Sciences, Kyoto University to Institute of Laboratory Animals (Kyo) in 1998.
Coat Color: a,B,C,h(tan-hooded),p,R
Inbred Generations: F13
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-12-29)
Research Usage Ophthalmology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23115,939,351 - 116,045,141RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.03121,235,230 - 121,340,932RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03128,669,534 - 128,777,078RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.43116,308,387 - 116,416,414RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
5. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Vollrath D, etal., Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12584-9.

Region

Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
Rnor_5.0 RCS/Kyo (KyushuU) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Carries gene for retinal dystrophy, which causes over-production of rhodopsin and progressive loss of photoreceptor cells beginning in the third postnatal week. Cataracts develop in 24% of rats and there is a 4% incidence of microphthalmia. 69668
strain_reproduction Good breeding performance. 69668