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Strain Registration

Strain: TM/Kyo

Symbol: TM/Kyo
Strain: TM
Substrain: Kyo
Full Name: tester moriyama rat
RGD ID: 1302623
Citation ID: RRID:RGD_1302623
Ontology ID: RS:0000934
Alleles: Rab38ru
Variant(s): Rab38ru-var1
Also Known As: MDC-02-27; NBRP Rat No: 0014
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Tester Moriyama rat derived from Long-Evans at Aichi Cancer Center, were transferred to Moriyama Mental Disease Hospital and Nagoya University. Inbred Line was established at Nagoya University. From Shionogi & Co., Ltd. to Kyo in 1976 .
Coat Color: a,B,C,h,P,r
Inbred Generations: F71
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2024-09-24)
Research Usage Hematology





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. TM rats: a model for platelet storage pool deficiency. Hamada S, etal., Exp Anim 1997 Jul;46(3):235-9.
2. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
3. The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain. Oiso N, etal., Mamm Genome 2004 Apr;15(4):307-14.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Rab38ru-var1 chr1 142182614 142182614 G A point_mutation mRatBN7.2
Rab38ru-var1 chr1 152072764 152072764 G A point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy These have a light brown hooded coat pattern which resembles FHH rats; these are used as a coat color tester line. 1302447
strain_life_disease A good model for platelet storage pool deficiency with low blood serotinin level than the BN rats. The blood coagulation time and platelet count is normal. 1302447
strain_other Have Rab38 Met1Ile mutation which is responsible for fawn-hooded pigmentary dilution and platelet storage pool deficiency 1300411
strain_reproduction Have good breeding performance. 1302447

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-04 TM/Kyo  tester moriyama rat  TM/Kyo  tester moriyama rat  Name updated 68913 APPROVED