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Strain Registration

Strain: W-Ghsrem1Ottc

Symbol: W-Ghsrem1Ottc
Strain: W-Ghsrem1
Substrain: Ottc
RGD ID: 12879386
Citation ID: RRID:RRRC_00827
Ontology ID: RS:0004406
Alleles: Ghsrem1Ottc
Also Known As: WI-Ghsrem1Ottc; W-Ghsrem1Ottc; GHSR KO rat; W-Ghsr^[em1Ottc]
Type: mutant
Available Source: Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Origination: Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Description: The CRISPR/Cas9 genome editing system was used to generate this knock out rat strain with 846- bp deletion in the rat Ghsr gene. The rat strain had Ghsr exon1 deletion in the genome and did not express detectable Ghsr mRNA in brain regions.
Last Known Status: Cryopreserved Sperm; Cryorecovery (as of 2018-12-04)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82112,196,158 - 112,201,666RGD_MAPPER_PIPELINE
mRatBN7.22110,268,489 - 110,271,865RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02113,065,953 - 113,071,265RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.02132,784,207 - 132,789,319RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.42113,269,623 - 113,272,999RGD_MAPPER_PIPELINERGSC_v3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Personal Communication with OTTC Personal Communication with OTTC
2. Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model. Zallar LJ, etal., Int J Obes (Lond). 2018 Jan 30. pii: 10.1038/s41366-018-0013-5. doi: 10.1038/s41366-018-0013-5.
3. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Zallar LJ, etal., J Neuroendocrinol. 2018 Nov 20:e12663. doi: 10.1111/jne.12663.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-16 W-Ghsrem1Ottc    W-Ghsrem1Ottc    Symbol and/or name change 68913 APPROVED
2017-05-08 W-Ghsrem1Ottc    WI-Ghsrem1Ottc    Symbol updated 68687 APPROVED
2017-05-08 W-Ghsrem1Ottc    WI-Ghsrem1Ottc    Symbol updated 68687 APPROVED
2017-05-08 WI-Ghsrem1Ottc    W-Ghsrem1Ottc    Symbol updated 68687 APPROVED
2017-05-08 WI-Ghsrem1Ottc    W-Ghsrem1Ottc    Symbol updated 68687 APPROVED
2017-05-08 W-Ghsrem1Ottc    WI-Ghsrem1Ottc    Symbol updated 68687 APPROVED
2017-05-08 W-Ghsrem1Ottc    WI-Ghsrem1Ottc    Symbol updated 68687 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00827 RGD