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Strain Registration

Strain: CV/Iet

Symbol: CV/Iet
Strain: CV
Substrain: Iet
RGD ID: 11041108
Citation ID: RRID:RGD_11041108
Ontology ID: RS:0004169
Also Known As: Curly Vibrissae; NBRP Rat No: 0817
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: The Laboratory of Reproductive Toxicology at the Institute of Environmental Toxicology has been maintaining a Wistar derived PD strain of rats. In 1986, 1 female and 2 males exhibiting very short and sparse vibrissae were found in a litter of 7 parented by a pd/pd female and phenotypically normal pd/+ male. In 2008, a male Wistar rat and F56 female were crossed, and obtained heterozygous rats were sib-mated. After that, sib mating between homozygous rats was started.
Coat Color: albino
Inbred Generations: F11
Last Known Status: Cryopreserved Sperm






References

References - curated
# Reference Title Reference Citation
1. Curly vibrissae, a new mutation in the Wistar-derived rat. Fujii S, etal., Congenit Anom (Kyoto). 2003 Mar;43(1):65-71.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Genetic analysis reveal that the mutant characteristics are inherited as autosomal recessive traits and the cv gene located on 10 Mb area＿D8Got1-D8Got13) near Chr 8 centromere. This mutant rat is abnormally curled appearance of the vibrissae. The cv/cv homozygous rats have a small number of short and/or curly vibrissae around the nose. The vibrissae on the cheek and/or above the eyes are also short and curled; however, no vibrissa appears on the lower mandible. Although hair growth seems to be retarded, the outer hairs showed nearly normal length by 10 weeks of age. The outer hairs of matured cv/cv rats appear silky and translucent. The adult mutant rats often exhibit loss of hair on the head and/or back. Lactating females usually lose their abdominal hair. There is no histopathological change in the skin. 1302502
strain_reproduction Sib mating (crossing between homozygous rats) 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CV/Iet    CV/Iet    Name updated 68913 APPROVED
2016-03-21 CV/Iet    CV/Iet    Name updated 68913 APPROVED