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Strain Registration

Strain: WIC-Dmdem3Kykn

Symbol: WIC-Dmdem3Kykn
Strain: WIC-Dmdem3
Substrain: Kykn
RGD ID: 11040985
Citation ID: RRID:RGD_11040985
Ontology ID: RS:0004165
Alleles: Dmd
Also Known As: Dystrophin mutated rat (In-Frame-2); W-Dmdem3Kykn; NBRP Rat No: 0781; WI-Dmdem3Kykn; W-Dmdem3Kykn; WIC-Dmd^[em3Kykn]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Keitaro Yamanouchi, The University of Tokyo
Description: By CRISPR/Cas9 system, mutation was introduced in dystrophin (Dmd) gene of Wistar-Imamichi rat: Deletion of exon3 to exon16 (a part of intron 3 remain). This strain died out in 2015.
Coat Color: albino
Inbred Generations: F1
Last Known Status: Extinct (as of 2017-05-02)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X51,070,098 - 53,437,845RGD_MAPPER_PIPELINE
mRatBN7.2X47,272,324 - 49,504,219RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X51,149,358 - 53,519,271RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0X51,475,950 - 53,700,033RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4X71,501,362 - 71,671,414RGD_MAPPER_PIPELINERGSC_v3.4






References

References - curated
# Reference Title Reference Citation
1. Generation of muscular dystrophy model rats with a CRISPR/Cas system. Nakamura K, etal., Sci Rep. 2014 Jul 9;4:5635. doi: 10.1038/srep05635.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This rat exhibits similar phenotypes to Becker muscular dystrophy(BMD): focal skeletal muscle necrosis and regeneration at 8 weeks of age and muscular hypertrophy at 8 months of age in affected male rats. 1302502
strain_reproduction In male rats, spermatogenesis is not observed (infertility). This IF2 strain ＿W-Dmdem3Kykn＿died out in 2015. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-02 WIC-Dmdem3Kykn    W-Dmdem3Kykn    Symbol and/or name change 68913 APPROVED
2017-05-02 W-Dmdem3Kykn    WI-Dmdem3Kykn    Symbol updated 68687 APPROVED
2017-05-02 W-Dmdem3Kykn    WI-Dmdem3Kykn    Symbol updated 68687 APPROVED