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Strain Registration

Strain: WIC-Dmdem2Kykn

Symbol: WIC-Dmdem2Kykn
Strain: WIC-Dmdem2
Substrain: Kykn
RGD ID: 11040980
Citation ID: RRID:RGD_11040980
Ontology ID: RS:0004163
Alleles: Dmdem2Kykn
Also Known As: Dystrophin mutated rat (In-Frame-1); W-Dmdem2Kykn; NBRP Rat No: 0780; WI-Dmdem2Kykn; W-Dmdem2Kykn; WIC-Dmd^[em2Kykn]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: By CRISPR/Cas9 system, mutation was introduced in dystrophin (Dmd) gene of Wistar-Imamichi rat: deletion of exon3 to exon16
Coat Color: albino
Inbred Generations: F1
Last Known Status: Cryopreserved Embryo (as of 2017-05-02)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X51,070,098 - 53,437,845RGD_MAPPER_PIPELINE
mRatBN7.2X47,272,324 - 49,504,219RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X51,149,358 - 53,519,271RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0X51,475,950 - 53,700,033RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4X71,501,362 - 71,671,414RGD_MAPPER_PIPELINERGSC_v3.4






References

References - curated
# Reference Title Reference Citation
1. Generation of muscular dystrophy model rats with a CRISPR/Cas system. Nakamura K, etal., Sci Rep. 2014 Jul 9;4:5635. doi: 10.1038/srep05635.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This rat exhibits similar phenotypes to Becker muscular dystrophy(BMD): focal skeletal muscle necrosis and regeneration at 8 weeks of age and muscular hypertrophy at 8 months of age in affected male rats. 1302502
strain_reproduction mating between heterozygous female and wild-type male rats (Affected male rats are infertile.) 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-02 WIC-Dmdem2Kykn    W-Dmdem2Kykn    Symbol and/or name change 68913 APPROVED
2017-05-02 W-Dmdem2Kykn    WI-Dmdem2Kykn    Symbol updated 68687 APPROVED
2017-05-02 W-Dmdem2Kykn    WI-Dmdem2Kykn    Symbol updated 68687 APPROVED