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Strain Registration

Strain: F344-Tg(Prp-APP,Prp-PS1)19/Rrrc

Symbol: F344-Tg(Prp-APP,Prp-PS1)19/Rrrc
Strain: F344-Tg(Prp-APP,Prp-PS1)19
Substrain: Rrrc
RGD ID: 10401208
Citation ID: RRID:RRRC_00699
Ontology ID: RS:0004041
Also Known As: F344-Tg(APP-Prp.PS1-Prp)19; TgF344-AD
Type: transgenic
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: The strain was coinjected with two transgenes: one contains the human amyloid beta (A4) precursor protein (hAPP) gene with the Swedish mutation (K595N/M596L) driven by mouse prion promoter (Prp). The other contains the human presenilin 1 gene (PS1) with a deletion of exon 9, also driven by the mouse prion promoter (Prp). Based on segregation patterns, it is believed that the two transgenes have integrated at the same chromosomal site.
Coat Color: White
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2019-02-20)





Disease Annotations     Click to see Annotation Detail View
tauopathy  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss. Cohen RM, etal., J Neurosci. 2013 Apr 10;33(15):6245-56. doi: 10.1523/JNEUROSCI.3672-12.2013.
2. Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer's disease. Pentkowski NS, etal., Neurobiol Aging. 2018 Jan;61:169-176. doi: 10.1016/j.neurobiolaging.2017.09.024. Epub 2017 Oct 5.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Mimics Alzheimer's disease pathology: amyloid plaques, neurofibrillary tangles, neuronal loss, neuroinflammation, age associated cognitive impairment 2292495
strain_other Preclinical studies of Alzheimer's disease including drug testing, study of molecular mechanisms underlying AD pathology and development of biomarkers 2292495
strain_reproduction Transgene positive X wild type F344/NHsd. 2292495
strain_reproduction Littersize: 8; Weaning age: 21 days 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-31 F344-Tg(Prp-APP,Prp-PS1)19/Rrrc    F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    Symbol updated 68687 APPROVED
2016-03-31 F344-Tg(Prp-APP,Prp-PS1)19/Rrrc    F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    Name updated 68913 APPROVED
2016-03-31 F344-Tg(Prp-APP,Prp-PS1)19/Rrrc    F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    Symbol updated 68687 APPROVED
2016-03-31 F344-Tg(Prp-APP,Prp-PS1)19/Rrrc    F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    Name updated 68913 APPROVED
2016-03-10 F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    F344-Tg(APP-Prp.PS1-Prp)19    Symbol updated 68687 APPROVED
2016-03-10 F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    F344-Tg(APP-Prp.PS1-Prp)19    Name updated 68913 APPROVED
2016-03-10 F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    F344-Tg(APP-Prp.PS1-Prp)19    Symbol updated 68687 APPROVED
2016-03-10 F344-Tg(Prp-APP-Prp,Prp-PS1)19/Rrrc    F344-Tg(APP-Prp.PS1-Prp)19    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00699 RGD