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Strain Registration

Strain: F344-Nfe2l2em2Kyo

Symbol: F344-Nfe2l2em2Kyo
Strain: F344-Nfe2l2em2
Substrain: Kyo
RGD ID: 10045600
Citation ID: RRID:RGD_10045600
Ontology ID: RS:0003935
Alleles: Nfe2l2em2Kyo
Variant(s): Nfe2l2em2Kyo-var1
Also Known As: Nrf2 +1; F344-Nfe2l2em2Kyo; NBRP Rat No: 0784; F344-Nfe2l2^[em2Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Zinc-finger nucleases (ZFNs) method targeting exon 5 of Nfe2l2 (Nrf2) (ACCACTGTCCCCAGCCCAgaggccACACTGACAGAGATGGAC) was used; This strain has a 1 bp insertion in Nfe2l2 gene.
Coat Color: Albino
Last Known Status: Unknown
Research Usage Neurobiology; Diabetes Obesity
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8381,001,529 - 81,031,165RGD_MAPPER_PIPELINE
mRatBN7.2360,595,852 - 60,595,853RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0362,499,178 - 62,499,179RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0369,041,641 - 69,069,190RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4358,366,693 - 58,394,116RGD_MAPPER_PIPELINERGSC_v3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Taguchi K, etal., Toxicol Sci. 2016 Jul;152(1):40-52. doi: 10.1093/toxsci/kfw065. Epub 2016 Apr 12.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nfe2l2em2Kyo-var1 chr3 60595852 60595853 - G insertion mRatBN7.2
Nfe2l2em2Kyo-var1 chr3 62499178 62499179 - G insertion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Expression level of target gene of Nrf2 was decreased by a deletion of Nrf2 transcription factor. 1302502
strain_reproduction mating between heterozygous male and heterozygous female 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 F344-Nfe2l2em2Kyo    F344-Nfe2l2em2Kyo    Symbol updated 68687 APPROVED
2016-03-16 F344-Nfe2l2em2Kyo    F344-Nfe2l2em2Kyo    Name updated 68913 APPROVED
2016-03-16 F344-Nfe2l2em2Kyo    F344-Nfe2l2em2Kyo    Symbol updated 68687 APPROVED
2016-03-16 F344-Nfe2l2em2Kyo    F344-Nfe2l2em2Kyo    Name updated 68913 APPROVED