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Strain Registration

Strain: WIC-Dmdem1Kykn

Symbol: WIC-Dmdem1Kykn
Strain: WIC-Dmdem1
Substrain: Kykn
RGD ID: 10045593
Citation ID: RRID:RGD_10045593
Ontology ID: RS:0003932
Alleles: Dmdem1Kykn
Also Known As: W-Dmdem1Kykn; Dystrophin mutated rat (Out of Frame-1); NBRP Rat No: 0779; WIC-Dmdem1Kykn; W-Dmdem1Kykn; WIC-Dmd^[em1Kykn]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: By CRISPR/Cas9 system, mutation was introduced in dystrophin (Dmd) gene of Wistar-Imamichi rat. The resulting mutation is a 329-bp deletion around exon 3 and 2-bp substitution in exon16.
Coat Color: Albino
Inbred Generations: F1
Last Known Status: Cryopreserved Sperm (as of 2016-12-08)
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X51,070,098 - 53,437,845RGD_MAPPER_PIPELINE
mRatBN7.2X47,272,324 - 49,504,219RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X51,149,358 - 53,519,271RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0X51,475,950 - 53,700,033RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4X71,501,362 - 71,671,414RGD_MAPPER_PIPELINERGSC_v3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Generation of muscular dystrophy model rats with a CRISPR/Cas system. Nakamura K, etal., Sci Rep. 2014 Jul 9;4:5635. doi: 10.1038/srep05635.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This rat exhibits similar phenotypes to Duchenne muscular dystrophy (DMD). Skeletal muscle degeneration from 4 weeks of age, myocardial necrosis and inflammation at 13 weeks, decrease in body weight from 6 month old 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-02 WIC-Dmdem1Kykn    W-Dmdem1Kykn    Symbol and/or name change 68913 APPROVED
2016-03-16 W-Dmdem1Kykn    W-Dmdem1Kykn    Symbol updated 68687 APPROVED
2016-03-16 W-Dmdem1Kykn    W-Dmdem1Kykn    Name updated 68913 APPROVED
2016-03-16 W-Dmdem1Kykn    W-Dmdem1Kykn    Symbol updated 68687 APPROVED
2016-03-16 W-Dmdem1Kykn    W-Dmdem1Kykn    Name updated 68913 APPROVED
2015-06-12 W-Dmdem1Kykn    W-Dmdem1Kykn    Symbol updated 68687 APPROVED
2015-06-12 W-Dmdem1Kykn    W-Dmdem1Kykn    Name updated 68913 APPROVED
2015-06-12 W-Dmdem1Kykn    W-Dmdem1Kykn    Symbol updated 68687 APPROVED
2015-06-12 W-Dmdem1Kykn    W-Dmdem1Kykn    Name updated 68913 APPROVED