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Strain Registration

Strain: SPRD-Anks6PKD/Fsn

Symbol: SPRD-Anks6PKD/Fsn
Strain: SPRD-Anks6PKD
Substrain: Fsn
RGD ID: 10043617
Citation ID: RRID:RGD_10043617
Ontology ID: RS:0003908
Alleles: Anks6PKD
Variant(s): Anks6PKD-var1
Also Known As: SPRD-Anks6m1Fsn; Cy rat; Han:SPRD-Cy; NBRP Rat No: 0684; SPRD-Anks6^[PKD]/Fsn
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This strain rats was provided to University of Kansas from Central Institute for Laboratory Animal Breeding (Hanover, Germany), and then was introduced to Fujita Health University.
Coat Color: Albino
Inbred Generations: F12
Last Known Status: Cryopreserved Sperm (as of 2018-04-20)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8566,112,770 - 66,112,770RGD_MAPPER_PIPELINE
mRatBN7.2561,317,180 - 61,317,180RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0562,650,971 - 62,650,971RGD_MAPPER_PIPELINERnor_6.0
Rnor_5.0567,163,440 - 67,204,853RGD_MAPPER_PIPELINERnor_5.0
RGSC_v3.4563,633,540 - 63,674,953RGD_MAPPER_PIPELINERGSC_v3.4






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Anks6PKD-var1 chr5 66112770 66112770 G A point_mutation GRCr8
Anks6PKD-var1 chr5 61317180 61317180 G A point_mutation mRatBN7.2
Anks6PKD-var1 chr5 62650971 62650971 G A point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The causative gene of this rat is named as Cy or Anks6 (Pkdr1). This gene product is SamCystin. Cy is inherited in an autosomal dominant manner. 1302502
strain_life_disease The Cy/Cy homozygous and Cy/+ heterozygous rats develop polycystic kidney disease (PKD). The Cy/Cy homozygous rats die of renal failure at around 3 weeks of age. In the Cy/+ heterozygous rats, female rats survive for over 1 year, but the life-span of male rats is within 1 year. In the Cy/+ heterozygous kidneys, cell growth is promoted by activation of signaling pathway such as ERK, and the levels of MCP-1 and osteopontin are increased. In addition, cell growth is promoted by androgen receptor-mediated activation of signaling pathway in the heterozygous male rats. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-20 SPRD-Anks6PKD/Fsn    SPRD-Anks6m1Fsn    Symbol updated 68687 APPROVED
2018-04-20 SPRD-Anks6PKD/Fsn    SPRD-Anks6m1Fsn    Symbol updated 68687 APPROVED