Advanced Search (OLGA)

Gene: Panx2 (pannexin 2) Rattus norvegicus

Analyze

Symbol:

Panx2

Name:

pannexin 2

RGD ID:

735191

Description:

Enables gap junction channel activity. Involved in cell-cell signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human PANX2 (pannexin 2); PARTICIPATES IN neuron-to-neuron signaling pathway via the electrical synapse; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

pannexin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PANX2 (pannexin 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Panx2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Panx2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PANX2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PANX2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Panx2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PANX2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PANX2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Panx2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Panx2 (pannexin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PANX2 (pannexin 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Panx2 (pannexin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	panx2 (pannexin 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	panx2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	122,018,937 - 122,032,009 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	122,018,937 - 122,032,004 (+)	Ensembl				GRCr8
mRatBN7.2	7	120,139,259 - 120,153,056 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	120,139,294 - 120,152,361 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	121,890,228 - 121,900,756 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	124,116,393 - 124,126,921 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	124,079,501 - 124,090,033 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	130,042,948 - 130,053,034 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	130,042,947 - 130,053,032 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	129,728,893 - 129,738,979 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	127,364,190 - 127,374,412 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	116,613,592 - 116,623,771 (+)	NCBI		Celera
RGSC_v3.1	7	127,398,419 - 127,408,176 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholangiocarcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-4,6-dinitrotoluene (EXP)

3-phenylprop-2-enal (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bortezomib (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

chromium(6+) (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

ethanol (ISO)

fipronil (EXP)

furan (EXP)

indole-3-methanol (EXP)

lead diacetate (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP,ISO)

naled (ISO)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

orphenadrine (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP)

permethrin (ISO)

phenylmercury acetate (ISO)

piperonyl butoxide (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

temozolomide (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell signaling (IBA,IMP)

monoatomic cation transport (IBA,IEA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

positive regulation of interleukin-1 production (IEA)

response to ischemia (ISO)

Cellular Component

cytoplasm (IEA,ISO)

endoplasmic reticulum membrane (IEA)

gap junction (IEA)

Golgi membrane (IEA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

channel activity (IEA)

gap junction channel activity (IMP)

gap junction hemi-channel activity (ISS)

protein binding (ISO)

protein-containing complex binding (IMP)

structural molecule activity (ISS)

wide pore channel activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

neuron-to-neuron signaling pathway via the electrical synapse (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Pannexins, a family of gap junction proteins expressed in brain.	Bruzzone R, etal., Proc Natl Acad Sci U S A 2003 Nov 11;100(23):13644-9. Epub 2003 Nov 3.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis.	Liu J, etal., PeerJ. 2019 Oct 31;7:e7968. doi: 10.7717/peerj.7968. eCollection 2019.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:15632090	PMID:16616526	PMID:17692470	PMID:19009624	PMID:20086016	PMID:20516070	PMID:21467198	PMID:22147915	PMID:22301733	PMID:28390953

Genomics

Comparative Map Data

Panx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	122,018,937 - 122,032,009 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	122,018,937 - 122,032,004 (+)	Ensembl				GRCr8
mRatBN7.2	7	120,139,259 - 120,153,056 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	120,139,294 - 120,152,361 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	121,890,228 - 121,900,756 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	124,116,393 - 124,126,921 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	124,079,501 - 124,090,033 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	130,042,948 - 130,053,034 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	130,042,947 - 130,053,032 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	129,728,893 - 129,738,979 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	127,364,190 - 127,374,412 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	116,613,592 - 116,623,771 (+)	NCBI		Celera
RGSC_v3.1	7	127,398,419 - 127,408,176 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

PANX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	50,170,731 - 50,180,295 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	50,170,731 - 50,180,295 (+)	Ensembl			hg38	GRCh38
GRCh37	22	50,609,160 - 50,618,724 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	48,951,317 - 48,960,848 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	22	48,911,646 - 48,921,176	NCBI
Celera	22	34,484,072 - 34,493,636 (+)	NCBI		Celera
Cytogenetic Map	22	q13.33	NCBI
HuRef	22	33,511,308 - 33,516,181 (+)	NCBI		HuRef
CHM1_1	22	50,567,900 - 50,577,463 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	50,677,468 - 50,687,032 (+)	NCBI		T2T-CHM13v2.0

Panx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	88,941,797 - 88,957,769 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	88,943,937 - 88,957,770 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	89,059,057 - 89,073,566 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	89,059,734 - 89,073,567 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	88,890,156 - 88,901,337 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	88,887,870 - 88,897,644 (+)	NCBI		MGSCv36	mm8
Celera	15	91,175,680 - 91,198,816 (+)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	44.57	NCBI

Panx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	33,220,140 - 33,224,344 (+)	Ensembl
ChiLan1.0	NW_004955413	33,220,145 - 33,224,241 (+)	NCBI	ChiLan1.0	ChiLan1.0

PANX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	60,075,546 - 60,085,200 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	62,761,947 - 62,771,600 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	30,398,717 - 30,408,358 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	49,404,516 - 49,409,063 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	49,404,624 - 49,408,045 (+)	Ensembl			panPan2	panpan1.1

PANX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	17,052,972 - 17,059,756 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	17,052,956 - 17,055,880 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	17,030,576 - 17,037,865 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	17,779,626 - 17,786,929 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	17,779,614 - 17,786,922 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	17,503,674 - 17,510,972 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	17,826,699 - 17,833,986 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	17,958,945 - 17,966,248 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Panx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	618,784 - 626,452 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936629	618,042 - 626,452 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936629	618,758 - 626,446 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PANX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	497,385 - 506,013 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	497,380 - 506,126 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	110,720,301 - 110,729,048 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PANX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	32,662,350 - 32,671,536 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	92,684,542 - 92,693,776 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Panx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	565,357 - 575,069 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	565,357 - 575,064 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Panx2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	258,368,371 - 258,381,028 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Panx2
84 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	169
Count of miRNA genes:	105
Interacting mature miRNAs:	135
Transcripts:	ENSRNOT00000048501
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	116269196	132020414	Rat
1582240	Sffal1	Serum free fatty acids level QTL 1	3.4	0.0021	blood free fatty acid amount (VT:0001553)	serum free fatty acids level (CMO:0000547)	7	118556868	125929417	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

RH134180

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	120,149,494 - 120,149,677 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	130,052,705 - 130,052,887	NCBI	Rnor6.0
Rnor_5.0	7	129,738,650 - 129,738,832	UniSTS	Rnor5.0
RGSC_v3.4	7	127,374,083 - 127,374,265	UniSTS	RGSC3.4
Celera	7	116,623,442 - 116,623,624	UniSTS
RH 3.4 Map	7	946.6	UniSTS
Cytogenetic Map	7	q34	UniSTS

RH139916

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	7	946.6	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	7	67	160	88	87	56	70	56	6	324	168	11	137	81	91	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ557016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ204587	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000089707 ⟹ ENSRNOP00000069647

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	122,018,937 - 122,031,585 (+)	Ensembl
mRatBN7.2 Ensembl	7	120,139,294 - 120,149,820 (+)	Ensembl
Rnor_6.0 Ensembl	7	130,042,947 - 130,053,032 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105173 ⟹ ENSRNOP00000076858

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	122,019,260 - 122,028,438 (+)	Ensembl
mRatBN7.2 Ensembl	7	120,139,617 - 120,148,795 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111032 ⟹ ENSRNOP00000085314

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	122,018,937 - 122,032,004 (+)	Ensembl
mRatBN7.2 Ensembl	7	120,139,294 - 120,152,361 (+)	Ensembl

RefSeq Acc Id:

NM_199409 ⟹ NP_955441

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,018,937 - 122,029,467 (+)	NCBI
mRatBN7.2	7	120,139,294 - 120,149,824 (+)	NCBI
Rnor_6.0	7	130,042,948 - 130,053,034 (+)	NCBI
Rnor_5.0	7	129,728,893 - 129,738,979 (+)	NCBI
RGSC_v3.4	7	127,364,190 - 127,374,412 (+)	RGD
Celera	7	116,613,592 - 116,623,771 (+)	RGD

Sequence:

show sequence

GGTAAACAGCCCCCCTCCCAGGCGGGAGCGGGCCGCGCGGCCCAGGCAGGATAGCCGCCGCCGC
CCCCGGGAGGGACGCAGGGCGCGGGCCAGCTACAGCGCACGGCGGGGGCGGCGGCGGCCCGGCG
CCCTGGCAGCTCGACCCCTCTCGCGGGGCGGCAGACCCCCGAGCCCCGCCGCATCCCCGCTGAC
ATCCCTCTTCCAGCGCCCTGCGCCCCGCGCCCCCGTGACCTCGGTCTCCGTCGCCCCCCGCCGC
CCTCTCTGGCGCGCGGCCCCGCCCGCGCCCCCCGCCCGTACCCCGCCGGGCCGCGCCCCCGCCC
CCCATGCACCACCTCCTGGAGCAGTCGGCGGACATGGCGACCGCGCTGCTGGCGGGCGAGAAGC
TGAGGGAGCTGATCCTGCCTGGCTCGCAGGACGACAAGGCGGGTGCGCTGGCCGCGCTGCTGCT
GCAGCTCAAGCTGGAACTGCCGTTCGACCGCGTGGTCACCATCGGCACCGTGCTGGTACCCATC
CTGCTGGTCACCCTGGTCTTCACCAAGAACTTCGCAGAGGAACCAATTTACTGTTATACTCCGC
ACAACTTCACCCGTGACCAGGCGCTGTACGCCCGTGGCTACTGCTGGACAGAGCTGCGGGATGC
CCTGCCCGGCGTGGATGCCAGCCTGTGGCCATCGCTGTTTGAGCACAAGTTCCTGCCCTACGCA
CTGCTGGCCTTTGCCGCCATCATGTATGTGCCCGCACTGGGCTGGGAGTTCCTGGCCTCCACGC
GCCTCACCTCCGAGCTCAACTTCCTGCTTCAGGAGATCGACAACTGCTACCACCGAGCCGCCGA
AGGTCGCGCCCCCAAGATTGAGAAGCAGATCCAGTCCAAGGGGCCAGGCATCACGGAGCGCGAG
AAGCGGGAAATCATTGAGAACGCTGAGAAGGAGAAGAGCCCTGAGCAGAATTTGTTTGAGAAGT
ACCTGGAGCGCCGGGGCCGCAGCAACTTCTTGGCCAAGCTGTACTTGGCGCGGCACGTACTGAT
CCTGCTACTCAGTGTGGTGCCCATCTCTTACCTATGCACATACTACGCCACCCAGAAGCAGAAC
GAGTTCACCTGCGCCCTGGGCGCCTCGCCTGACGGGCCGGTGGGTAGCGCCGGGCCCACGGTGC
GCGTCAGCTGTAAGCTGCCCTCCGTGCAGCTGCAGCGGATCATTGCGGGTGTGGACATCGTATT
GCTCTGCTTCATGAACCTCATCATCCTGGTCAACCTCATCCACCTCTTCATCTTCCGCAAGAGC
AACTTCATTTTTGACAAGCTGCACAAGGTGGGTATCAAGACGCGCCGGCAGTGGCGCCGCTCGC
AGTTCTGCGACATCAACATCCTGGCCATGTTCTGTAACGAGAACCGTGACCACATCAAGTCGCT
TAACCGGCTGGACTTCATCACCAACGAGAGCGACCTCATGTACGACAACGTGGTGCGGCAGCTT
CTGGCTGCCTTGGCTCAGTCTAACCACGACACCACGCCCACGGTTCGGGACTCAGGCATCCAGA
CCGTGGACCCCAGCATCAACCCCGCAGAGCCTGAGGGCTCTGCTGAGCCACCCGTGGTCAAGCG
GCCCCGTAAGAAAATGAAGTGGATCCCCACCAGCAACCCGCTGCCACAGCCCTTCAAGGAGCAG
CTGGCCATTATGCGCGTAGAAAACAGCAAGACTGAGAAGCCCAAACCTGTGCGCAGGAAGACAG
CCACGGATACACTTATTGCCCCGCTGCTGGACGCTGGTGCCCGGGCTGCCCACCACTACAAGGG
GAGTGGAGGTGATACAGGGCCCTCCTCTGCCCCGCCTGCTGCCTCTGAGAAAAAGCATACCCGG
CACTTCTCCTTGGATGTGCATCCCTATATCCTAGGCAGCAAGAAGGCCAAGACTGAAGCAGTAC
CCCCTGCCCTACCAGCCTCCCGGAGCCAGGAAGGTGGCTTCCTGTCCCAGACAGAGGAATGTGG
GCTGGGCTTGGCTGCAGCACCCACCAAAGATGCTCCGCTCCCTGAGAAGGAAATCCCATACCCC
ACAGAGTCTGCCCTGCCGTCTGGGGGCCCATTCCATGTGTGCTCACCCCCCACGGCCTCTGCTG
CTGCTTCCCTGTCACCGAGCAGCCTGGGCAAGGCTGACCCCCTCACCATCCTGAGCCGAAACGC
CACTCACCCCCTGCTCCACATCAGCACGTTGTACGAGGCCCGGGAAGAGGAGGAAGGAGGTCCC
TGTGCACCCTCAGACATGGGCGACCTCCTCAGCATACCCCCACCCCAGCAGATCCTCATCGCCA
CCTTCGAGGAGCCGAGAACAGTTGTGAGTACTGTGGAGTTTTGAGGGGCAGGGCCTCCCAGGCC
ACCAAAACCTCTCTGCGAGAGCCAGGGATGGCCCAGCTGAGCCTAGGCATGAGTAGATCCGAAC
TCTGCTCACCCAGTACCGCCCACAACCCCCAGCCTCCTGTCTGCATGCCACGGGGCCCAGCCCT
CCTTCCACCTGGCTCACCATGGCATCCACAAGTGCAGGCCGGGGCTCGAGCACAAGGTGGGAGA
GGGTGCCTACCCCAGCATCAGGCACCCCCCTCAGCATGCTGGGCCACAAGATGAAGAGTTTATT
TTTTTAGTGGGTTTTGTTGTGGGCTGACACAACTCAGCACACCCAGTTGGGCCCAGCCTAGGGT
AAGTGAGGACGGTGCTGGGGAAGGTGGTACTGGCCTCAGGACAGACCCCAGGGGTCACTCACTT
AAGGGCCTGGCCCCTACAGAGGGACCTGATACCTTCAGGTGGAGGGGGGACTGAGGGCTGCCCC
GGGTCCAAATCAACATGCACTTTCTCCACGTAGCCTGACACACACTTTATTTTTACTATGACTA
CTGTAACTGACGAGACTATTTATCCCCAGGAGAATTAGGGTGCATTTAAAGCAGAGGACGATGT
GTGTGAGTGGCCTAAGCAGACGTGGGTGTAAAAGTCCCAAGTAAGCAGGTGTGGGTACAAGCAC
CTGCCCGAGTGACTGAGTTTGCCAGAGATGCACAGTGCCCGTGCACGAGTAAACAAGCGAGCAG
GAGACAAGCCTGCTGTGAGTGAGCCTGAGTATGTGTGAGTGTGCGAGCGAGTGAGCAGCACCCA
CGTGAGCAGTGGGTGAGAGCAGGCGTAGGCGCCAGGGTACAAACGAGGGAAGGGATACAACGCA
ATAACCACATCCCCTTCCCGGGTCCCCAGCTGCTGGCTGGACCGCTTCCCATGGGAGTCCAGGC
CCCACTGGCCCCACCCCTATTACCTCAGCCACGCGCCACGTGACCGAAGTATTAACAAGGTAGC
ACTGAGCATATCAATAAATACTATTCTGATAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039079619 ⟹ XP_038935547

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,019,260 - 122,032,009 (+)	NCBI
mRatBN7.2	7	120,139,259 - 120,152,385 (+)	NCBI

RefSeq Acc Id:

XM_039079620 ⟹ XP_038935548

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,019,260 - 122,032,009 (+)	NCBI
mRatBN7.2	7	120,139,261 - 120,152,385 (+)	NCBI

RefSeq Acc Id:

XM_039079621 ⟹ XP_038935549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,020,498 - 122,031,817 (+)	NCBI
mRatBN7.2	7	120,139,261 - 120,152,169 (+)	NCBI

RefSeq Acc Id:

XM_039079622 ⟹ XP_038935550

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,019,617 - 122,031,817 (+)	NCBI
mRatBN7.2	7	120,139,855 - 120,152,169 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_955441	(Get FASTA)	NCBI Sequence Viewer
	XP_038935547	(Get FASTA)	NCBI Sequence Viewer
	XP_038935548	(Get FASTA)	NCBI Sequence Viewer
	XP_038935549	(Get FASTA)	NCBI Sequence Viewer
	XP_038935550	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAD89523	(Get FASTA)	NCBI Sequence Viewer
	EDL76530	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069647
	ENSRNOP00000069647.2
	ENSRNOP00000085314
GenBank Protein	P60571	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_955441 ⟸ NM_199409

- UniProtKB:

P60571 (UniProtKB/Swiss-Prot), A6K7I7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPIL
LVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYAL
LAFAAIMYVPALGWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREK
REIIENAEKEKSPEQNLFEKYLERRGRSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNE
FTCALGASPDGPVGSAGPTVRVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSN
FIFDKLHKVGIKTRRQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLL
AALAQSNHDTTPTVRDSGIQTVDPSINPAEPEGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQL
AIMRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDTGPSSAPPAASEKKHTRH
FSLDVHPYILGSKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAPLPEKEIPYPT
ESALPSGGPFHVCSPPTASAAASLSPSSLGKADPLTILSRNATHPLLHISTLYEAREEEEGGPC
APSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF

hide sequence

Ensembl Acc Id:

ENSRNOP00000069647 ⟸ ENSRNOT00000089707

RefSeq Acc Id:	XP_038935547 ⟸ XM_039079619
- Peptide Label:	isoform X1
- UniProtKB:	A6K7I7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038935548 ⟸ XM_039079620
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A329 (UniProtKB/TrEMBL), A6K7I7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038935549 ⟸ XM_039079621
- Peptide Label:	isoform X3
- UniProtKB:	R9PXY9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038935550 ⟸ XM_039079622
- Peptide Label:	isoform X3
- UniProtKB:	R9PXY9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000076858 ⟸ ENSRNOT00000105173

Ensembl Acc Id:

ENSRNOP00000085314 ⟸ ENSRNOT00000111032

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P60571-F1-model_v2	AlphaFold	P60571	1-674	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735191	AgrOrtholog
BioCyc Gene	G2FUF-32470	BioCyc
Ensembl Genes	ENSRNOG00000055530	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000089707	ENTREZGENE
	ENSRNOT00000089707.2	UniProtKB/Swiss-Prot
	ENSRNOT00000111032	ENTREZGENE
InterPro	Innexin	UniProtKB/Swiss-Prot
	Pannexin	UniProtKB/Swiss-Prot
KEGG Report	rno:362979	UniProtKB/Swiss-Prot
NCBI Gene	362979	ENTREZGENE
PANTHER	PANNEXIN-2	UniProtKB/Swiss-Prot
	PTHR15759	UniProtKB/Swiss-Prot
Pfam	Innexin	UniProtKB/Swiss-Prot
PhenoGen	Panx2	PhenoGen
PROSITE	PANNEXIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000055530	RatGTEx
UniProt	A0A8I5XVH3_RAT	UniProtKB/TrEMBL
	A0A8I6A329	ENTREZGENE, UniProtKB/TrEMBL
	A6K7I7	ENTREZGENE, UniProtKB/TrEMBL
	P60571	ENTREZGENE, UniProtKB/Swiss-Prot
	R9PXY9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Panx2	pannexin 2			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

RGD Manual Annotations