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Gene: Gprc6a (G protein-coupled receptor, class C, group 6, member A) Rattus norvegicus

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Symbol:

Gprc6a

Name:

G protein-coupled receptor, class C, group 6, member A

RGD ID:

735077

Description:

Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of testosterone biosynthetic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and calcium-mediated signaling. Located in plasma membrane. Orthologous to human GPRC6A (G protein-coupled receptor class C group 6 member A); INTERACTS WITH bisphenol A; streptozocin; warfarin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor family C group 6 member A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	31,464,818 - 31,486,121 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	31,464,818 - 31,486,121 (-)	Ensembl				GRCr8
mRatBN7.2	20	30,922,106 - 30,943,412 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	30,922,106 - 30,943,412 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	31,933,050 - 31,954,357 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	31,323,970 - 31,345,277 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	32,056,871 - 32,078,866 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	32,607,653 - 32,628,953 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	32,607,653 - 32,628,953 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	34,391,559 - 34,412,859 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	30,235,065 - 30,256,951 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	32,337,968 - 32,359,241 (-)	NCBI		Celera
RGSC_v3.1	20	30,248,864 - 30,270,751 (-)	NCBI
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

disorder of sexual development (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

lipopolysaccharide (ISO)

ozone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

streptozocin (EXP)

warfarin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA,ISO)

calcium-mediated signaling (ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

positive regulation of insulin secretion involved in cellular response to glucose stimulus (IEA,ISO)

regulation of testosterone biosynthetic process (IEA,ISO,ISS)

response to amino acid (IEA,ISO)

signal transduction (IEA)

Cellular Component

cell surface (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IDA,IEA,ISO)

Molecular Function

G protein-coupled peptide receptor activity (IEA,ISO)

G protein-coupled receptor activity (IBA,IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.	Wellendorph P and Brauner-Osborne H, Gene 2004 Jun 23;335:37-46.
7.	The rat GPRC6A: cloning and characterization.	Wellendorph P, etal., Gene. 2007 Jul 15;396(2):257-67. Epub 2007 Mar 24.

Additional References at PubMed

PMID:16199532	PMID:28280242

Genomics

Comparative Map Data

Gprc6a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	31,464,818 - 31,486,121 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	31,464,818 - 31,486,121 (-)	Ensembl				GRCr8
mRatBN7.2	20	30,922,106 - 30,943,412 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	30,922,106 - 30,943,412 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	31,933,050 - 31,954,357 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	31,323,970 - 31,345,277 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	32,056,871 - 32,078,866 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	32,607,653 - 32,628,953 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	32,607,653 - 32,628,953 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	34,391,559 - 34,412,859 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	30,235,065 - 30,256,951 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	32,337,968 - 32,359,241 (-)	NCBI		Celera
RGSC_v3.1	20	30,248,864 - 30,270,751 (-)	NCBI
Cytogenetic Map	20	q11	NCBI

GPRC6A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	116,792,085 - 116,829,240 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	116,792,085 - 116,829,083 (-)	Ensembl			hg38	GRCh38
GRCh37	6	117,113,248 - 117,150,246 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	117,219,941 - 117,256,891 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	117,219,940 - 117,256,891	NCBI
Celera	6	117,856,343 - 117,893,293 (-)	NCBI		Celera
Cytogenetic Map	6	q22.1	NCBI
HuRef	6	114,692,894 - 114,729,847 (-)	NCBI		HuRef
CHM1_1	6	117,377,275 - 117,414,231 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	117,975,811 - 118,012,987 (-)	NCBI		T2T-CHM13v2.0

Gprc6a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	51,490,919 - 51,507,554 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	51,490,919 - 51,507,557 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	51,614,823 - 51,631,458 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	51,614,823 - 51,631,461 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	51,334,629 - 51,351,264 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	51,303,238 - 51,319,873 (-)	NCBI		MGSCv36	mm8
Celera	10	52,458,235 - 52,474,872 (-)	NCBI		Celera
Cytogenetic Map	10	B3	NCBI
cM Map	10	25.66	NCBI

Gprc6a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	137,809 - 159,481 (-)	Ensembl
ChiLan1.0	NW_004955436	137,809 - 159,481 (-)	NCBI	ChiLan1.0	ChiLan1.0

GPRC6A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	136,806,917 - 136,843,842 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	134,699,926 - 134,736,844 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	114,601,360 - 114,638,286 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	118,744,929 - 118,781,099 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	118,744,929 - 118,781,099 (-)	Ensembl			panPan2	panpan1.1

GPRC6A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	57,191,210 - 57,212,008 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	57,191,325 - 57,212,027 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	57,982,884 - 58,007,086 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	57,369,654 - 57,393,866 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	57,373,198 - 57,393,895 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	57,264,046 - 57,288,251 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	57,112,172 - 57,136,372 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	57,740,939 - 57,765,164 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gprc6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	107,932,060 - 107,951,693 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936658	38,931 - 58,534 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936658	38,931 - 58,534 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPRC6A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	44,854,512 - 44,874,777 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	44,852,731 - 44,875,518 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	50,131,381 - 50,153,730 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPRC6A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	56,994,267 - 57,028,736 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	56,995,346 - 57,028,305 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	29,330,675 - 29,363,823 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gprc6a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624798	12,865,731 - 12,888,685 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624798	12,865,834 - 12,888,598 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gprc6a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	29,284,822 - 29,307,056 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gprc6a
134 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	24
Count of miRNA genes:	22
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000000451
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26689362	56021148	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20745585	56021148	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	26689362	56021148	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26792353	56021148	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26689362	56021148	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26689362	56021148	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	1	2	4	14	1	2	1	15	3	2	8	9	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ535460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000451 ⟹ ENSRNOP00000000451

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	31,464,818 - 31,486,121 (-)	Ensembl
mRatBN7.2 Ensembl	20	30,922,106 - 30,943,412 (-)	Ensembl
Rnor_6.0 Ensembl	20	32,607,653 - 32,628,953 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112868 ⟹ ENSRNOP00000080341

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	31,464,818 - 31,486,121 (-)	Ensembl
mRatBN7.2 Ensembl	20	30,922,106 - 30,943,412 (-)	Ensembl

RefSeq Acc Id:

NM_001271106 ⟹ NP_001258035

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	31,464,818 - 31,486,121 (-)	NCBI
mRatBN7.2	20	30,922,106 - 30,943,412 (-)	NCBI
Rnor_6.0	20	32,607,653 - 32,628,953 (-)	NCBI
Rnor_5.0	20	34,391,559 - 34,412,859 (-)	NCBI
Celera	20	32,337,968 - 32,359,241 (-)	NCBI

Sequence:

show sequence

CATGAACTGAGCAAATGAGACAGCATGGCCCTATCATTTGTATTTATTACTTGCTTCATGATTC
TTCTTGATACCTCCCAGTCTTGTCATACCCCAGATGACTTCGTGGCTATCACTTCTCCTGGACA
TATCATGATTGGTGGTTTGTTTGCCATTCACGAAAAAATGTTGTCCTCAGATGACCATCCCAGG
CAACCACAAATCCAGAAGTGTGTTGGTTTTGAAATATCAGTGTTTCTTCAAACTCTGGCTATGA
TACACAGCATTGAGATGATCAATAACTCAAGCCTGTTGTCCGGAGTTAAGCTGGGGTATGAAAT
CTATGACACTTGTACTGAAGTCACAGCGGCAATGGCTGCCACCCTGAGGTTCCTCTCTAAATTC
AACTGCTCTAGAGAAACCGTGATCTTTCAATGTGACTATTCCAGCTACGTGCCAAGGGTCAAGG
CCATCATAGGTGCTGGCTACTCTGAAATATCCATGGCGGTCTCGAGGATGCTGAATTTACAGCT
CATGCCACAGGTGAGTTATGAATCCACTGCAGAAATCCTGAGTGACAAAATCCGCTTTCCTTCG
TTTTTACGAACCGTGCCCAGTGACTTCTACCAAACTAAAGCAATGGCCCACCTGATCCGACAAT
CCGGATGGAACTGGGTTGGTGCCATAACAACCGACGATGATTATGGAAGACTAGCGCTCAACAC
ATTTGCAATCCAGGCTGCTGAAAACAATGTGTGCATCGCCTTCAAAGAGGTTCTGCCAGCCTTC
CTCTCAGATAATACCATTGAAGTGAGAATCAACCAGACTCTGGAGAAAATCATTGCCGAAGCCC
AGGTCAATGTCATCGTGGTGTTTCTTAGGAAATTCCACGTCTTCAATCTCTTCAACAAAGCCAT
CGAGAGGAAAATAAGTAAGATCTGGATTGCTAGTGATAACTGGTCAACTGCTGCCAAGATTATC
ACCATTCCCAATGTTAAGAAGCTTGGCAAAGTAGTGGGCTTTACTTTTAGGAGAGGAAATATGT
CTTCTTTCCATTCTTTTCTTCAAACTCTGCATATGTACCCCAGTGACAATAACAAACCCCTACA
TGAGTTTGCCATGCTTTTTTCTGCCTGTAAACACATCAAAGATGGTGATTTGAGCCAATGCATT
TCCAACTATTCTCAGGCAACTTGGACCTATGACACTACCAAGACCATTGAGACCCATTTATTCA
AGAGAAATGACTTCCTTTGGCATTATACTGAGCCAGGACTCATTCACAGCATTCAGCTTGCTGT
GCTTGCCTTGGGCCATGCCATCCGGGATCTGTGCCAAGATCGAGACTGCCAGAAACCCAACGCC
TTTCAGCCATGGGAGCTACTTGCGGTGCTGAAAAACGTGACATTCACTGACGGAAAAAACTCAT
TTCATTTTGATGCCCATGGGGATTTAAATACTGGTTACGAGGTGGTGCTCTGGAAAGAGACTAA
CGGCCTCATGACTGTCACGAAGATGGCAGAATATGACCTGCAGCATGACGTCTTCATCACCACA
AACCAAGAAACAAAGCATGAATTCAGGAAACTTAAGCAAATTCTATCTAAATGCTCCAAAGAAT
GCATTCCTGGTCAAATGAAGAAAGCCACAGGAAGCCAACACAGCTGTTGCTATGAATGTGTGAA
CTGCCCAGAAAACCACTACAGTAATGAGACAGACATGGATCACTGCCTCGTATGCAACAACGAA
ACCCACTGGGCCCCAGTAAGGAGCACGATGTGCTTCGAGAAGGAAGTGGAGTATCTTGACTGGG
ATGACTCCTTGGCTCTCCTCCTCATTGCCCTCTCCCTACTTGGAATTGCCTTTGTTCTGGCCGT
TGGCATAATATTTACAAGAAACCTGAAGACACCTGTGGTGAAATCATCTGGGGGATTAGTGGTC
TGTTACGTGATGCTCGCCTGCCATGCCCTCAACTTTGCCAGCACAGGCTTTTTTATTGGAGAAC
CACAGGACTTCACGTGCAAGACCAGGCAGACCCTGTTTGGCGTGAGCTTTACTCTGTGTGTCTC
CTGTATTTTGACGAAGTCCCTGAAAATTTTGCTAGCCTTCAGCTTCGACCCCACGCTGAAGACA
TTCCTGAAGTGTCTCTATAGGCCAGTCCCCATTGTCCTTACCTGCACGGGCATTCAAGTGGTCA
TTTGCACGCTTTGGCTGGTCCTGGCAGCACCTACTGTGGAAGAGAACACCTCCTTGCCTAGAGT
CATTATCCTAGAATGTGAGGAGGGATCTGCACTGGCGTTTGGCACCATGCTGGGCTACATTGCA
GTTCTGGCCTTCATTTGTTTTGTATTTGCATTCAAGGGGAGGAAGCTTCCTGAGAATTACAACG
AAGCTAAGTTCCTGACCTTTGGGATGCTGATTTACTTCATAGCTTGGATCACATTCATCCCAGT
CTATGCTACCACTTTCGGCAAGTATTTGCCCGCTGTGGAGATCATAGTCATTCTGATATCCAAC
TATGGTATCCTCTGCTGTACATTCTTCCCCAAGTGCTACATTATTCTTTGCAAGCAAAAGACTA
ACACTAAGTCAGTCTTCCTCCAGATGGTTTACAATTACTCTGCTCACAGCGTGGACAGCCTTGC
CTTGAGTCACGTATCCCTGGACTCCGCCAGCCACAGTACTGCAACAACCAACCCGAGGCCTGGT
AACAAGACTGCAGCCTGTCAGAATTACAAACATCTTCCTGTACAAGTGCTTGCTCACACAGGCA
TGGAAAAGACTATGCACGCGTCTAAAACTTTGCATCAGAAAAGAAGTTCAAGTATATGACTGAG
TTCTCAGGAGAGGCTATGATTCCCCAATAAGATGTTTCTGGTGATGGCTGCAAATTGTGTATTT
ATTTTTCTTAGCAAATACATCTTGGGTTTTTGTTGTTTGTTTGGTTTCTGTTTTTCTTCTTTGC
TTTTTGGGGTTCTTCTTTCTACCACTTTCTTGAACACTCTGTTCAACTCATTCTGTTTAACAAT
CTGCTAATAAAAAATAGTTTCCATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258035	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAD59483	(Get FASTA)	NCBI Sequence Viewer
	EDL92950	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000451
	ENSRNOP00000000451.3
GenBank Protein	Q70VB1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001258035 ⟸ NM_001271106
- Peptide Label:	precursor
- UniProtKB:	Q70VB1 (UniProtKB/Swiss-Prot), A6K472 (UniProtKB/TrEMBL), A0A8I6G4E9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALSFVFITCFMILLDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRQPQIQKCV GFEISVFLQTLAMIHSIEMINNSSLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVI FQCDYSSYVPRVKAIIGAGYSEISMAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSD FYQTKAMAHLIRQSGWNWVGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEV RINQTLEKIIAEAQVNVIVVFLRKFHVFNLFNKAIERKISKIWIASDNWSTAAKIITIPNVKKL GKVVGFTFRRGNMSSFHSFLQTLHMYPSDNNKPLHEFAMLFSACKHIKDGDLSQCISNYSQATW TYDTTKTIETHLFKRNDFLWHYTEPGLIHSIQLAVLALGHAIRDLCQDRDCQKPNAFQPWELLA VLKNVTFTDGKNSFHFDAHGDLNTGYEVVLWKETNGLMTVTKMAEYDLQHDVFITTNQETKHEF RKLKQILSKCSKECIPGQMKKATGSQHSCCYECVNCPENHYSNETDMDHCLVCNNETHWAPVRS TMCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAVGIIFTRNLKTPVVKSSGGLVVCYVMLACH ALNFASTGFFIGEPQDFTCKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPTLKTFLKCLYRP VPIVLTCTGIQVVICTLWLVLAAPTVEENTSLPRVIILECEEGSALAFGTMLGYIAVLAFICFV FAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYATTFGKYLPAVEIIVILISNYGILCCTF FPKCYIILCKQKTNTKSVFLQMVYNYSAHSVDSLALSHVSLDSASHSTATTNPRPGNKTAACQN YKHLPVQVLAHTGMEKTMHASKTLHQKRSSSI hide sequence

Ensembl Acc Id:

ENSRNOP00000000451 ⟸ ENSRNOT00000000451

Ensembl Acc Id:

ENSRNOP00000080341 ⟸ ENSRNOT00000112868

Protein Domains

G-protein coupled receptors family 3 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q70VB1-F1-model_v2	AlphaFold	Q70VB1	1-928	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735077	AgrOrtholog
BioCyc Gene	G2FUF-3661	BioCyc
Ensembl Genes	ENSRNOG00000000401	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000000451	ENTREZGENE
	ENSRNOT00000000451.6	UniProtKB/Swiss-Prot
Gene3D-CATH	2.10.50.30	UniProtKB/Swiss-Prot
	3.40.50.2300	UniProtKB/Swiss-Prot
InterPro	ANF_lig-bd_rcpt	UniProtKB/Swiss-Prot
	GPCR_3	UniProtKB/Swiss-Prot
	GPCR_3_9-Cys_dom	UniProtKB/Swiss-Prot
	GPCR_3_9-Cys_sf	UniProtKB/Swiss-Prot
	GPCR_3_C	UniProtKB/Swiss-Prot
	GPCR_3_Ca_sens_rcpt-rel	UniProtKB/Swiss-Prot
	GPCR_3_CS	UniProtKB/Swiss-Prot
	Peripla_BP_I	UniProtKB/Swiss-Prot
KEGG Report	rno:294394	UniProtKB/Swiss-Prot
NCBI Gene	294394	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A	UniProtKB/Swiss-Prot
	PTHR24061	UniProtKB/Swiss-Prot
Pfam	7tm_3	UniProtKB/Swiss-Prot
	ANF_receptor	UniProtKB/Swiss-Prot
	NCD3G	UniProtKB/Swiss-Prot
PhenoGen	Gprc6a	PhenoGen
PRINTS	CASENSINGR	UniProtKB/Swiss-Prot
	GPCRMGR	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F3_2	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F3_4	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000401	RatGTEx
Superfamily-SCOP	SSF53822	UniProtKB/Swiss-Prot
UniProt	A0A8I6G4E9	ENTREZGENE, UniProtKB/TrEMBL
	A6K472	ENTREZGENE, UniProtKB/TrEMBL
	GPC6A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-02-06	Gprc6a	G protein-coupled receptor, class C, group 6, member A	Gprc6a	G protein-coupled receptor, family C, group 6, member A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Gprc6a	G protein-coupled receptor, family C, group 6, member A			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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