Amigo2 (adhesion molecule with Ig like domain 2) - Rat Genome Database

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Gene: Amigo2 (adhesion molecule with Ig like domain 2) Rattus norvegicus
Analyze
Symbol: Amigo2
Name: adhesion molecule with Ig like domain 2
RGD ID: 727911
Description: Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of neuron apoptotic process. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human AMIGO2 (adhesion molecule with Ig like domain 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ali1; Alivin 1; alivin-1; AMIGO-2; amphoterin induced gene 2; amphoterin-induced protein 2; transmembrane protein AMIGO2; transmembrane protein AMIGO2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,270,639 - 130,273,735 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7130,270,554 - 130,282,218 (-)EnsemblGRCr8
mRatBN7.27128,391,493 - 128,394,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,390,412 - 128,394,695 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7130,188,505 - 130,191,609 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,414,037 - 132,417,141 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,329,495 - 132,332,533 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07138,704,124 - 138,707,221 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7138,704,126 - 138,707,221 (-)Ensemblrn6Rnor6.0
Rnor_5.07138,327,613 - 138,330,710 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47135,966,794 - 135,969,747 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7124,880,421 - 124,883,447 (-)NCBICelera
RGSC_v3.17136,043,230 - 136,046,184 (-)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-Nitrosopyrrolidine  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA)
nucleus  (IEA)
plasma membrane  (IEA,NAS)

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases. Kanda Y, etal., Sci Rep. 2017 Mar 8;7:43567. doi: 10.1038/srep43567.
3. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. Kuja-Panula J, etal., J Cell Biol 2003 Mar 17;160(6):963-73.
4. AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis. Li Z, etal., Brain Behav Immun. 2017 May;62:110-123. doi: 10.1016/j.bbi.2017.01.009. Epub 2017 Feb 1.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
7. Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. Ono T, etal., J Neurosci 2003 Jul 2;23(13):5887-96.
8. AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation. Park H, etal., J Cell Biol. 2015 Nov 9;211(3):619-37. doi: 10.1083/jcb.201503113.
9. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Rabenau KE, etal., Oncogene. 2004 Jun 24;23(29):5056-67. doi: 10.1038/sj.onc.1207681.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24613359  


Genomics

Comparative Map Data
Amigo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,270,639 - 130,273,735 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7130,270,554 - 130,282,218 (-)EnsemblGRCr8
mRatBN7.27128,391,493 - 128,394,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,390,412 - 128,394,695 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7130,188,505 - 130,191,609 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07132,414,037 - 132,417,141 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07132,329,495 - 132,332,533 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07138,704,124 - 138,707,221 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7138,704,126 - 138,707,221 (-)Ensemblrn6Rnor6.0
Rnor_5.07138,327,613 - 138,330,710 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47135,966,794 - 135,969,747 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7124,880,421 - 124,883,447 (-)NCBICelera
RGSC_v3.17136,043,230 - 136,046,184 (-)NCBI
Cytogenetic Map7q36NCBI
AMIGO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,075,707 - 47,079,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,075,707 - 47,080,902 (-)Ensemblhg38GRCh38
GRCh371247,469,490 - 47,473,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361245,755,757 - 45,759,915 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341245,755,756 - 45,759,915NCBI
Celera1246,266,530 - 46,270,780 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1244,500,413 - 44,504,656 (-)NCBIHuRef
CHM1_11247,434,869 - 47,439,118 (-)NCBICHM1_1
T2T-CHM13v2.01247,036,477 - 47,040,734 (-)NCBIT2T-CHM13v2.0
Amigo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,141,955 - 97,145,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,142,006 - 97,145,168 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381597,244,074 - 97,247,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1597,244,125 - 97,247,287 (-)Ensemblmm10GRCm38
MGSCv371597,074,505 - 97,077,718 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361597,072,159 - 97,075,156 (-)NCBIMGSCv36mm8
Celera1599,379,756 - 99,382,756 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1552.91NCBI
Amigo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,134,736 - 6,138,075 (-)Ensembl
ChiLan1.0NW_0049555006,134,736 - 6,138,075 (-)NCBIChiLan1.0ChiLan1.0
AMIGO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21047,087,432 - 47,090,754 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11247,084,383 - 47,087,467 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01241,652,954 - 41,656,393 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11242,525,099 - 42,528,399 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1242,525,858 - 42,527,426 (+)EnsemblpanPan2panpan1.1
AMIGO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,507,426 - 7,510,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,507,489 - 7,509,054 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2738,798,999 - 38,802,268 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0277,573,450 - 7,576,716 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl277,573,601 - 7,576,762 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1277,509,723 - 7,513,046 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,552,000 - 7,555,266 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,041,956 - 39,045,226 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amigo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494568,004,585 - 68,007,754 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365125,157,175 - 5,159,818 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365125,157,076 - 5,160,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMIGO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl577,642,195 - 77,645,753 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1577,642,144 - 77,645,748 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2580,650,537 - 80,653,629 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMIGO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11143,281,634 - 43,285,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1143,282,518 - 43,284,083 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037203,104,609 - 203,108,095 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amigo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248165,184,536 - 5,187,659 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248165,184,423 - 5,189,691 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Amigo2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11270,077,227 - 270,080,125 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amigo2
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:27
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000009199
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 84 59 6 346 184 11 142 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009199   ⟹   ENSRNOP00000009199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7138,704,126 - 138,707,221 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097759   ⟹   ENSRNOP00000085327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7130,270,554 - 130,282,218 (-)Ensembl
mRatBN7.2 Ensembl7128,390,412 - 128,394,695 (-)Ensembl
RefSeq Acc Id: NM_182816   ⟹   NP_877968
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,270,639 - 130,273,735 (-)NCBI
mRatBN7.27128,391,493 - 128,394,589 (-)NCBI
Rnor_6.07138,704,125 - 138,707,221 (-)NCBI
Rnor_5.07138,327,613 - 138,330,710 (-)NCBI
RGSC_v3.47135,966,794 - 135,969,747 (-)RGD
Celera7124,880,421 - 124,883,447 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063263369   ⟹   XP_063119439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,270,639 - 130,273,614 (-)NCBI
RefSeq Acc Id: XM_063263370   ⟹   XP_063119440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,270,639 - 130,273,575 (-)NCBI
RefSeq Acc Id: NP_877968   ⟸   NM_182816
- Peptide Label: precursor
- UniProtKB: Q80ZD6 (UniProtKB/Swiss-Prot),   Q7TNJ4 (UniProtKB/Swiss-Prot),   A0A0G2JSI9 (UniProtKB/TrEMBL),   A6KC34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009199   ⟸   ENSRNOT00000009199
Ensembl Acc Id: ENSRNOP00000085327   ⟸   ENSRNOT00000097759
RefSeq Acc Id: XP_063119439   ⟸   XM_063263369
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119440   ⟸   XM_063263370
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNJ4-F1-model_v2 AlphaFold Q7TNJ4 1-520 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695613
Promoter ID:EPDNEW_R6136
Type:single initiation site
Name:Amigo2_1
Description:adhesion molecule with Ig like domain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07138,707,239 - 138,707,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727911 AgrOrtholog
BioCyc Gene G2FUF-32201 BioCyc
Ensembl Genes ENSRNOG00000007032 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097759 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
InterPro AMIGO UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:300186 UniProtKB/Swiss-Prot
NCBI Gene 300186 ENTREZGENE
PANTHER AMPHOTERIN-INDUCED PROTEIN UniProtKB/Swiss-Prot
  AMPHOTERIN-INDUCED PROTEIN 2 UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
PhenoGen Amigo2 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007032 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
UniProt A0A0G2JSI9 ENTREZGENE, UniProtKB/TrEMBL
  A6KC34 ENTREZGENE, UniProtKB/TrEMBL
  AMGO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80ZD6 ENTREZGENE
UniProt Secondary Q80ZD6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Amigo2  adhesion molecule with Ig like domain 2  LOC100364402  transmembrane protein AMIGO2-like  Data merged from RGD:2321058 1643240 APPROVED
2010-05-05 LOC100364402  transmembrane protein AMIGO2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Amigo2  adhesion molecule with Ig like domain 2    amphoterin induced gene 2  Name updated 1299863 APPROVED
2005-07-08 Amigo2  amphoterin induced gene 2    transmembrane protein AMIGO2  Name updated 1299863 APPROVED